製品の概要

  • 製品名
    AG 490
  • 製品の詳細
    JAK2/3 inhibitor
  • 生理活性の詳細
    JAK2/3 inhibitor (IC50 values are ~10 and 25 μM, respectively). Inhibits downstream activation of STAT5a/b. Effects synaptic plasticity and cytokine-independent cell growth in vitro and spatial learning, memory and tumor cell invasion in vivo.
  • 精製度
    > 99%

法規制情報

製品の特性

参考文献

This product has been referenced in:
  • Nicolas CS  et al. The Jak/STAT pathway is involved in synaptic plasticity. Neuron 73:374-90 (2012). Read more (PubMed: 22284190) »
  • Abe M  et al. The polycythemia vera-associated Jak2 V617F mutant induces tumorigenesis in nude mice. Int Immunopharmacol 9:870-7 (2009). Read more (PubMed: 19327411) »
  • Kirken RA  et al. Tyrphostin AG-490 inhibits cytokine-mediated JAK3/STAT5a/b signal transduction and cellular proliferation of antigen-activated human T cells. J Leukoc Biol 65:891-9 (1999). Read more (PubMed: 10380915) »
  • Meydan N  et al. Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor. Nature 379:645-8 (1996). Read more (PubMed: 8628398) »

See 1 Publication for this product

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