製品の概要

  • 製品名AF-DX 384
  • 製品の詳細
    M2/M4 antagonist
  • 生理活性の詳細M2/M4 receptor antagonist (Kd values are 1 (M2), 2.2 (M4), 15 (M3) and 55 nM (M1)). Low blood-brain barrier permeability.
  • 精製度> 98%

製品の特性

    AF-DX 384 (ab120146) 使用論文

    This product has been referenced in:
    • Mickala P  et al. In vivo binding, pharmacokinetics and metabolism of the selective M2 muscarinic antagonists [3H]AF-DX 116 and [3H]AF-DX 384 in the anesthetized rat. Nucl Med Biol 23:173-9 (1996). Read more (PubMed: 8868291) »
    • Miller JH  et al. Binding of [3H]AF-DX 384 to cloned and native muscarinic receptors. J Pharmacol Exp Ther 259:601-7 (1991). Read more (PubMed: 1941609) »
    • Dörje F  et al. Antagonist binding profiles of five cloned human muscarinic receptor subtypes. J Pharmacol Exp Ther 256:727-33 (1991). Read more (PubMed: 1994002) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"