Anti-Adipose Triglyceride Lipase 抗体 (ab77591)

製品の概要

  • 製品名
    Anti-Adipose Triglyceride Lipase antibody
    Adipose Triglyceride Lipase 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to Adipose Triglyceride Lipase
  • アプリケーション
    適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide:

    PARPHGPEDKDQ

    , corresponding to internal sequence amino acids 266-277 of Human Adipose Triglyceride Lipase (NP_065109.1)

  • ポジティブ・コントロール
    • Human adipose lysates

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab77591 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
ELISA
  • 追加情報
    Peptide ELISA: Antibody detection limit dilution 1/8000.
    WB: Use at a concentration of 0.2 - 0.6 µg/ml. Detects a band of approximately 55 kDa (predicted molecular weight: 55 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes. May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion.
    • 組織特異性
      Highest expression in adipose tissue. Also detected in heart, skeletal muscle, and portions of the gastrointestinal tract. Detected in normal retina and retinoblastoma cells. Detected in retinal pigment epithelium and, at lower intensity, in the inner segments of photoreceptors and in the ganglion cell layer of the neural retina (at protein level).
    • パスウェイ
      Glycerolipid metabolism; triacylglycerol degradation.
    • 関連疾患
      Note=Genetic variations in PNPLA2 may be associated with risk of diabetes mellitus type 2.
      Defects in PNPLA2 are the cause of neutral lipid storage disease with myopathy (NLSDM) [MIM:610717]; also known as neutral lipid storage disease without ichthyosis. NSLDM is a neutral lipid storage disorder (NLSD) with myopathy but without ichthyosis. NLSDs are characterized by the presence of triglyceride-containing cytoplasmic droplets in leukocytes and in other tissues, including bone marrow, skin, and muscle. Individuals with NLSDM did not show obesity, in spite of a defect in triglyceride degradation in fibroblasts and in marked triglyceride storage in liver, muscles, and other visceral cells.
    • 配列類似性
      Contains 1 patatin domain.
    • 発生段階
      Induced during differentiation of primary preadipocytes to adipocytes. Expression increased from fetal to adult in retinal pigment epithelium.
    • 細胞内局在
      Lipid droplet. Cell membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • 1110001C14Rik antibody
      • Adipose triglyceride lipase antibody
      • ATGL antibody
      • ATGL DESNUTRIN antibody
      • Calcium independent phospholipase A2 antibody
      • Calcium-independent phospholipase A2 antibody
      • Desnutrin antibody
      • EC 3.1.1.3 antibody
      • FP17548 antibody
      • IPLA2 zeta antibody
      • IPLA2-zeta antibody
      • Mutant patatin like phospholipase domain containing 2 antibody
      • Patatin like phospholipase domain containing 2 antibody
      • PATATIN LIKE PHOSPHOLIPASE DOMAIN CONTAINING PROTEIN 2 antibody
      • Patatin-like phospholipase domain-containing protein 2 antibody
      • PEDF R antibody
      • PHOSPHOLIPASE A2 CALCIUM INDEPENDENT ZETA antibody
      • Pigment epithelium derived factor antibody
      • Pigment epithelium-derived factor antibody
      • plpl antibody
      • plpl2 antibody
      • PLPL2_HUMAN antibody
      • Pnpla2 antibody
      • Transport secretion protein 2 antibody
      • Transport secretion protein 2.2 antibody
      • Transport-secretion protein 2 antibody
      • Triglyceride hydrolase antibody
      • TTS 2.2 antibody
      • TTS2 antibody
      • TTS2.2 antibody
      • ZETA antibody
      see all

    画像

    • Anti-Adipose Triglyceride Lipase antibody (ab77591) at 0.2 µg/ml + human adipose lysate in RIPA buffer at 35 µg

      Predicted band size : 55 kDa
      Observed band size : 55 kDa

    プロトコール

    参考文献

    ab77591 has not yet been referenced specifically in any publications.

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