製品の概要

  • 製品名
    Anti-Adiponectin Receptor 1 antibody
    Adiponectin Receptor 1 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to Adiponectin Receptor 1
  • 特異性
    Recognizes Human ADPR1 Receptor. Not likely to cross react with ADPR2.
  • アプリケーション
    適用あり: WB, IHC-P, ICCmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Chicken, Cow, Cat, Pig, Xenopus laevis
  • 免疫原

    Synthetic peptide:

    CYAARIPERFFPGKFDIWFQSHQIF

    , corresponding to C terminal amino acids 317-340 of Human Adiponectin Receptor 1

  • ポジティブ・コントロール
    • Human liver tissue and human muscle tissue

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab77611 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
IHC-P
ICC
  • 追加情報
    ICC: 1/400 (acetone fixed cells).
    IHC-P: 1/250. Recommended buffer: 10 mM KHPO4, 140 mM NaCl, pH 7.2.
    WB: 1/1000. Predicted molecular weight: 42 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin.
    • 組織特異性
      Widely expressed. Highly expressed in skeletal muscle. Expressed at intermediate level in brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Weakly expressed in colon, thymus and small intestine.
    • 配列類似性
      Belongs to the ADIPOR family.
    • ドメイン
      The N-terminus is known to be cytoplasmic while the C-terminus is known to be extracellular.
    • 細胞内局在
      Membrane. Localized to the cell membrane and intracellular organelles.
    • Information by UniProt
    • 参照データベース
    • 別名
      • ACDCR1 antibody
      • ADIPO R1 antibody
      • Adiponectin receptor protein 1 antibody
      • ADIPOR 1 antibody
      • Adipor1 antibody
      • ADR1_HUMAN antibody
      • CGI 45 antibody
      • CGI 45 protein antibody
      • CGI-45 antibody
      • CGI45 antibody
      • CGI45 protein antibody
      • FLJ25385 antibody
      • FLJ42464 antibody
      • PAQR1 antibody
      • Progestin and adipoQ receptor family member I antibody
      • TESBP1A antibody
      see all

    画像

    • Paraffin section of human liver tissue stained using antibody to human ADPR1 receptor C-terminus ab77611 at 1/250 dilution.
    • Paraffin section of human muscle tissue stained using antibody to human ADPR1 receptor C-terminus ab77611 at 1/250 dilution.

    参考文献

    This product has been referenced in:
    • Basu S  et al. Cellular Expression of Cyclooxygenase, Aromatase, Adipokines, Inflammation and Cell Proliferation Markers in Breast Cancer Specimen. PLoS One 10:e0138443 (2015). Read more (PubMed: 26431176) »
    • Jeong YJ  et al. Expression of leptin, leptin receptor, adiponectin, and adiponectin receptor in ductal carcinoma in situ and invasive breast cancer. J Breast Cancer 14:96-103 (2011). IHC . Read more (PubMed: 21847403) »

    See all 2 Publications for this product

    レビューと Q&A

    Abcam guarantees this product to work in the species/application used in this Abreview.
    Application
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Sample
    Human Tissue sections (Liver)
    Specification
    Liver
    Fixative
    Paraformaldehyde
    Antigen retrieval step
    Heat mediated - Buffer/Enzyme Used: Citric acid
    Permeabilization
    No
    Blocking step
    Normal goat serum as blocking agent for 15 minute(s) · Concentration: 10% · Temperature: 25°C
    Username

    Abcam user community

    Verified customer

    投稿 Apr 08 2010

    Application
    Flow Cytometry
    Sample
    Human Cell (mesothelioma)
    Specification
    mesothelioma
    Fixation
    non-fix
    Permeabilization
    No
    Gating Strategy
    R2
    Username

    Abcam user community

    Verified customer

    投稿 Jan 27 2010

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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