Anti-AC3 抗体 (ab125093)
Key features and details
- Rabbit polyclonal to AC3
- Suitable for: WB, ICC/IF, IHC-FrFl
- Reacts with: Rat, Human
- Isotype: IgG
製品の概要
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製品名
Anti-AC3 antibody
AC3 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to AC3 -
由来種
Rabbit -
アプリケーション
適用あり: WB, ICC/IF, IHC-FrFlmore details -
種交差性
交差種: Rat, Human
交差が予測される動物種: Mouse, Chinese hamster -
免疫原
Synthetic peptide corresponding to Rat AC3 aa 1100-1200 (C terminal) conjugated to keyhole limpet haemocyanin (Cysteine residue).
Database link: P21932 -
ポジティブ・コントロール
- Rat olfactory epithelium and frontal cortex lysates; Mixed neuron-glial cultures.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
バッファー
Constituent: PBS -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab125093の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/5000 - 1/10000. Detects a band of approximately 160-200 kDa (predicted molecular weight: 129 kDa).
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ICC/IF |
1/500 - 1/1000.
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IHC-FrFl |
1/10000.
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特記事項 |
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WB
1/5000 - 1/10000. Detects a band of approximately 160-200 kDa (predicted molecular weight: 129 kDa). |
ICC/IF
1/500 - 1/1000. |
IHC-FrFl
1/10000. |
ターゲット情報
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機能
Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration. -
組織特異性
Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle. -
配列類似性
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Contains 2 guanylate cyclase domains. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 109 Human
- Entrez Gene: 104111 Mouse
- Entrez Gene: 64508 Rat
- Omim: 600291 Human
- SwissProt: O60266 Human
- SwissProt: Q8VHH7 Mouse
- SwissProt: P21932 Rat
- Unigene: 727540 Human
see all -
別名
- AC-III antibody
- AC3 antibody
- ADCY3 antibody
see all
画像
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Free foating immunohistochemistry of rat hippocampus stained with ab125093 at 1/10000 staining AC3 (red). A mouse antibody staining MECP2 (green), DNA is revealed with DAPI (blue).
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ab125093, at 1/500, staining AC3 in mixed neuron-glial cultures by Immunofluorescence (red). A mouse monoclonal antibody staining of aII-spectrin (green) is also shown.
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All lanes : Anti-AC3 antibody (ab125093) at 1/5000 dilution
Lane 1 : Rat olfactory epithelium lysate
Lane 2 : Rat frontal cortex lysate
Predicted band size: 129 kDa
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (11)
ab125093 は 11 報の論文で使用されています。
- Zhang WW et al. Peripheral ablation of type III adenylyl cyclase induces hyperalgesia and eliminates KOR-mediated analgesia in mice. JCI Insight 7:N/A (2022). PubMed: 34914639
- Kowal TJ et al. Distribution of prototypical primary cilia markers in subtypes of retinal ganglion cells. J Comp Neurol 530:2176-2187 (2022). PubMed: 35434813
- Zhang X et al. Endogenous glutamate determines ferroptosis sensitivity via ADCY10-dependent YAP suppression in lung adenocarcinoma. Theranostics 11:5650-5674 (2021). PubMed: 33897873
- Li ST et al. Regeneration of olfactory neuroepithelium in 3-methylindole-induced anosmic rats treated with intranasal chitosan. Biomaterials 271:120738 (2021). PubMed: 33711565
- Tan Y et al. Impaired hypocretin/orexin system alters responses to salient stimuli in obese male mice. J Clin Invest 130:4985-4998 (2020). PubMed: 32516139