製品の概要

  • 製品名Anti-ADCK3 antibody
    ADCK3 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to ADCK3
  • 特異性ab64816 detects endogenous levels of total CABC1 protein.
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    A synthetic peptide derived from an internal region of human CABC1

  • ポジティブ・コントロール
    • Extracts from HepG2 and mouse muscle cells.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab64816 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Detects a band of approximately 52 kDa (predicted molecular weight: 72 kDa).
ELISA 1/10000.

ターゲット情報

  • 機能May be a chaperone-like protein essential for the proper conformation and functioning of protein complexes in the respiratory chain.
  • 組織特異性Ubiquitously expressed with a relatively greater abundance in heart and skeletal muscle.
  • 関連疾患Defects in ADCK3 are a cause of coenzyme Q10 deficiency (CoQ10 deficiency) [MIM:607426]. CoQ10 deficiency is an autosomal recessive disorder with variable manifestations. It can be associated with three main clinical phenotypes: a predominantly myopathic form with central nervous system involvement, an infantile encephalomyopathy with renal dysfunction and an ataxic form with cerebellar atrophy.
    Defects in ADCK3 are the cause of spinocerebellar ataxia autosomal recessive type 9 (SCAR9) [MIM:612016]; also known as autosomal recessive cerebellar ataxia type 2 (ARCA2). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR9 is an autosomal recessive form characterized by gait ataxia and cerebellar atrophy with slow progression and few associated features. Patients can manifest brisk tendon reflexes and Hoffmann sign, mild psychomotor retardation, mild axonal degeneration of the sural nerve, exercise intolerance and elevated serum lactate.
  • 配列類似性Belongs to the protein kinase superfamily. ADCK protein kinase family.
    Contains 1 protein kinase domain.
  • 細胞内局在Mitochondrion.
  • Information by UniProt
  • 参照データベース
  • 別名
    • aarF domain containing protein kinase 3 antibody
    • aarF domain-containing protein kinase 3 antibody
    • ADCK 3 antibody
    • Adck3 antibody
    • ADCK3_HUMAN antibody
    • ARCA2 antibody
    • CABC 1 antibody
    • CABC1 antibody
    • Chaperone ABC1 (activity of bc1 complex S.pombe) like antibody
    • Chaperone ABC1 activity of bc1 complex homolog antibody
    • Chaperone ABC1 like antibody
    • Chaperone activity of bc1 complex like antibody
    • Chaperone activity of bc1 complex like mitochondrial antibody
    • Chaperone activity of bc1 complex-like antibody
    • Chaperone-ABC1-like antibody
    • Coenzyme Q8 homolog antibody
    • COQ 8 antibody
    • COQ10D4 antibody
    • COQ8 antibody
    • COQ8, S. cerevisiae, homolog of antibody
    • MGC4849 antibody
    • mitochondrial antibody
    • OTTHUMP00000035734 antibody
    • OTTHUMP00000035737 antibody
    • SCAR9 antibody
    see all

Anti-ADCK3 antibody 画像

  • All lanes : Anti-ADCK3 antibody (ab64816) at 1/500 dilution

    Lane 1 : Extracts from HepG2 cells
    Lane 2 : Extracts from mouse muscle cells
    Lane 3 : Extracts from mouse muscle cells with immunising peptide at 5 µg

    Lysates/proteins at 5 µg per lane.


    Predicted band size : 72 kDa
    Observed band size : 52 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 24 kDa,75 kDa. We are unsure as to the identity of these extra bands.

Anti-ADCK3 antibody (ab64816) 使用論文

This product has been referenced in:
  • Deng MY  et al. Frontal-Subcortical Protein Expression following Prenatal Exposure to Maternal Inflammation. PLoS One 6:e16638 (2011). WB ; Mouse . Read more (PubMed: 21347362) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"