製品の概要

  • 製品名Anti-ADAMTS9 antibody
  • 製品の詳細
    Rabbit polyclonal to ADAMTS9
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Rat, Cow, Dog, Xenopus laevis, Chimpanzee
  • 免疫原

    Synthetic peptide:

    CFDGKHFNINGLLPN

    , corresponding to amino acids 657-670 of Human ADAMTS9.

  • ポジティブ・コントロール
    • HEK 293 cell lysate.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab32565 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.5 µg/ml. Predicted molecular weight: 217 kDa.

ターゲット情報

  • 関連性ADAMTS proteases are secreted enzymes containing a prometalloprotease domain of the reprolysin type. The ADAMTS proteases function in processing of procollagens and von Willebrand factor as well as catabolism of aggrecan, versican and brevican. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. ADAMTS9 is closest in homology to ADAMTS20, sharing 54% overall identity, and like ADAMTS20 ADAMTS9 gas a GON like domain at the carboxyterminal end. The GON domain at the carboxyterminal end is similar to the GON1 protein in C. elegans, mutations of which lead to defective gonadal development. ADAMTS9 is expressed in ovary and testis, but little is known about the role of ADAMTS9 in reproductive organs. ADAMTS9 is also expressed in the heart, placenta, lung, skeletal tissue, and pancreas, so the protein must have wider functions than just gonadal development. ADAMTS9, like ADAMTS20, has a total of 15 thrombospondin like domains. The first TS domain begins shortly after the catalytic and disintegrin domains. TS domains 2 to 6 follow a spacer domain, followed by linker domain 1, then TS domains 7 & 8, linker domain 2, and then TS domains 9 to 15. In other ADAMTS proteins the TS motifs are thought to bind to the ECM. The ADAMTS proteins contain at least one prohormone convertase cleavage site, although it appears that one site is used preferentially, and cleavage of the propeptide domain at this site generates active enzymes. For ADAMTS9, this site is the RRTKR sequence, and the mature ADAMTS9 has an aminoterminal sequence of FLSYPR. The catalytic site of ADAMTS9 is most like ADAMTS1, 14 and 15, with an HExxHVFNMxH sequence, perhaps giving these enzymes some shared specificity.
  • 細胞内局在Secreted protein; extracellular space; extracellular matrix.
  • 参照データベース
  • 別名
    • A disintegrin and metalloproteinase with thrombospondin motifs 9 antibody
    • A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 9 antibody
    • A disintegrin like and metalloprotease with thrombospondin type 1 motif 9 antibody
    • ADAM metallopeptidase with thrombospondin type 1 motif 9 antibody
    • ADAM TS 9 antibody
    • ADAM TS9 antibody
    • ADAMTS 9 antibody
    • FLJ42955 antibody
    • KIAA1312 antibody
    see all

Anti-ADAMTS9 antibody (ab32565) 使用論文

ab32565 has not yet been referenced specifically in any publications.

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