製品の概要

  • 製品名Anti-ADAMTS4 antibody
    ADAMTS4 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to ADAMTS4
  • 特異性ab111905 is specific for ADAMTS4 and shows no cross-reactivity with other ADAMTS family members.
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Cow, Human, Pig
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic peptide: C-

    VMAHVDPEEP

    (with a Cysteine residue linker), corresponding to amino acids 390-399 of Mouse ADAMTS4 according to Q8BNJ2.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab111905 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 90 kDa. This antibody detects ADAMTS4 at ~68, ~53 and 30 kDa protein representing ADAMTS4 and its proteolytic fragments. Depending on the extent of C-terminal processing, several smaller bands may also be seen using this antibody.

ターゲット情報

  • 機能Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-
    -Ala-393' site.
  • 組織特異性Expressed in brain, lung and heart. Expressed at very low level in placenta and skeletal muscles.
  • 配列類似性Contains 1 disintegrin domain.
    Contains 1 peptidase M12B domain.
    Contains 1 TSP type-1 domain.
  • ドメインThe spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • 翻訳後修飾The precursor is cleaved by a furin endopeptidase.
  • 細胞内局在Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • 参照データベース
  • 別名
    • A disintegrin and metalloproteinase with thrombospondin motifs 4 antibody
    • A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 4 antibody
    • A disintegrin like and metalloprotease with thrombospondin type 1 motif 4 antibody
    • ADAM metallopeptidase with thrombospondin type 1 motif 4 antibody
    • ADAM TS 4 antibody
    • ADAM TS4 antibody
    • ADAM-TS 4 antibody
    • ADAM-TS4 antibody
    • ADAMTS 2 antibody
    • ADAMTS 4 antibody
    • ADAMTS-4 antibody
    • ADAMTS2 antibody
    • ADAMTS4 antibody
    • ADAMTS4 protein antibody
    • ADMP 1 antibody
    • ADMP-1 antibody
    • ADMP1 antibody
    • Aggrecanase 1 antibody
    • Aggrecanase-1 antibody
    • Aggrecanase1 antibody
    • ATS4_HUMAN antibody
    • KIAA0688 antibody
    see all

Anti-ADAMTS4 antibody (ab111905) 使用論文

ab111905 has not yet been referenced specifically in any publications.

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There are currently no Abreviews or Questions for ab111905.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"