製品の概要

  • 製品名Anti-ADAMTS2 antibody
    ADAMTS2 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to ADAMTS2
  • アプリケーション適用あり: WB, IHC-Frmore details
  • 種交差性
    交差種: Rat, Human
  • 免疫原

    Recombinant fragment: KHNDIDVFMP TLPVPTVAME VRPSPSTPLE VPLNASSTNA TEDHPETNAV DEPYKIHGLE DEVQPPNLIP RRPSPYEKTR NQRIQELIDE MRKKEMLGK, corresponding to amino acids 1112-1211 of Human ADAMTS2

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab56735 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 135 kDa.
IHC-Fr Use at an assay dependent concentration. PubMed: 24343133

ターゲット情報

  • 機能Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis.
  • 組織特異性Expressed at high level in skin, bone, tendon and aorta and at low levels in thymus and brain.
  • 関連疾患Defects in ADAMTS2 are the cause of Ehlers-Danlos syndrome type 7C (EDS7C) [MIM:225410]. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS7C is marked by extremely fragile tissues, hyperextensible skin and easy bruising. Facial skin contains numerous folds, as in the cutis laxa syndrome.
  • 配列類似性Contains 1 disintegrin domain.
    Contains 1 peptidase M12B domain.
    Contains 1 PLAC domain.
    Contains 4 TSP type-1 domains.
  • ドメインThe spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
  • 翻訳後修飾The precursor is cleaved by a furin endopeptidase.
  • 細胞内局在Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • 参照データベース
  • 別名
    • A disintegrin and metalloproteinase with thrombospondin motifs 2 antibody
    • A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 2 antibody
    • ADAM metallopeptidase with thrombospondin type 1 motif 2 antibody
    • ADAM TS 2 antibody
    • ADAM TS2 antibody
    • ADAM-TS 2 antibody
    • ADAM-TS2 antibody
    • ADAMTS 3 antibody
    • ADAMTS-2 antibody
    • ADAMTS2 antibody
    • ATS2_HUMAN antibody
    • EC 3.4.24.14 antibody
    • EDS VIIB antibody
    • EDS VIIC antibody
    • hPCPNI antibody
    • NPI antibody
    • PC I NP antibody
    • PC I-NP antibody
    • PCINP antibody
    • PCPNI antibody
    • pNPI antibody
    • Procollagen I N proteinase antibody
    • Procollagen I N-proteinase antibody
    • Procollagen I/II amino propeptide processing enzyme antibody
    • Procollagen I/II amino propeptide-processing enzyme antibody
    • Procollagen N endopeptidase antibody
    • Procollagen N-endopeptidase antibody
    see all

Anti-ADAMTS2 antibody 画像



  • Predicted band size : 135 kDa
    ADAMTS2 antibody (ab56735) at 1ug/lane + PC-12 cell lysate at 25ug/lane.

Anti-ADAMTS2 antibody (ab56735) 使用論文

This product has been referenced in:
  • Alarab M  et al. Expression of Extracellular Matrix-Remodeling Proteins Is Altered in Vaginal Tissue of Premenopausal Women With Severe Pelvic Organ Prolapse. Reprod Sci N/A:N/A (2013). WB, IHC-Fr ; Human . Read more (PubMed: 24343133) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"