製品の概要

  • 製品名Anti-ADAMTS17 antibody
    ADAMTS17 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to ADAMTS17
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 543-651 of Human ADAMTS17

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab58099 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 121 kDa.Can be blocked with Recombinant Human ADAMTS17 protein (ab153619).
IHC-P Use at an assay dependent concentration. PubMed: 19836009

ターゲット情報

  • 組織特異性Isoform 1 and isoform 2 are expressed at high levels in the lung, brain, whole eye and retina. Isoform 1 shows a weaker expression in the heart, kidney and skeletal muscle. Isoform 2 shows a weaker expression in the kidney, bone marrow and skeletal muscle. Isoform 1 and isoform 2 are expressed at high levels in the fetal heart, kidney, and whole eye, whereas a weak expression is seen in the fetal liver.
  • 関連疾患Defects in ADAMTS17 are the cause of Weill-Marchesani-like syndrome (WMLS) [MIM:613195]. It is a disorder characterized by many of the key features of Weill-Marchesani syndrome, including lenticular myopia, ectopia lentis, glaucoma, spherophakia and short stature. However, the characteristic brachydactyly or decreased joint flexibility of Weill-Marchesani syndrome are absent.
  • 配列類似性Contains 1 disintegrin domain.
    Contains 1 peptidase M12B domain.
    Contains 1 PLAC domain.
    Contains 5 TSP type-1 domains.
  • ドメインThe conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • 翻訳後修飾The precursor is cleaved by a furin endopeptidase.
  • 細胞内局在Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • 参照データベース
  • 別名
    • A disintegrin and metalloproteinase with thrombospondin motifs 17 antibody
    • A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 17 antibody
    • ADAM metallopeptidase with thrombospondin type 1 motif, 17 antibody
    • ADAM-TS 17 antibody
    • ADAM-TS17 antibody
    • ADAMTS 17 antibody
    • ADAMTS-17 antibody
    • ADAMTS17 antibody
    • ATS17_HUMAN antibody
    • EC 3.4.24. antibody
    • FLJ16363 antibody
    • FLJ32769 antibody
    • OTTHUMP00000194818 antibody
    see all

Anti-ADAMTS17 antibody 画像



  • Predicted band size : 121 kDa
    ADAMTS17 antibody (ab58099) at 1ug/lane + A-431 cell lysate at 25ug/lane.

Anti-ADAMTS17 antibody (ab58099) 使用論文

This product has been referenced in:
  • Morales J  et al. Homozygous mutations in ADAMTS10 and ADAMTS17 cause lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature. Am J Hum Genet 85:558-68 (2009). WB, IHC-P ; Human . Read more (PubMed: 19836009) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"