製品の概要

製品の詳細

  • 由来Synthetic

関連製品

特性

Our Abpromise guarantee covers the use of ab41249 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-ADAMTS13 antibody (ab28274)

    Western blot

    ELISA

  • 精製度> 95 % SDS-PAGE.

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 0.001% Tween 20, 30mM HEPES, 2mM EDTA, 150mM Sodium chloride, pH 6.75

関連情報

  • 別名
    • A disintegrin and metalloproteinase with thrombospondin motifs 13
    • A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 13
    • A disintegrin like and metalloprotease with thrombospondin type 1 motif 13
    • ADAM metallopeptidase with thrombospondin type 1 motif 13
    • ADAM TS
    • ADAM-TS 13
    • ADAM-TS13
    • ADAMTS 13
    • ADAMTS-13
    • ADAMTS13
    • ADAMTS13 protein
    • ATS13_HUMAN
    • C9orf8
    • TTP
    • Von Willebrand factor cleaving protease
    • von Willebrand factor-cleaving protease
    • vWF cleaving protease
    • vWF CP
    • vWF-cleaving protease
    • vWF-CP
    • vWFCP
    see all
  • 機能Cleaves the vWF multimers in plasma into smaller forms.
  • 組織特異性Plasma. Expressed primarily in liver.
  • 関連疾患Defects in ADAMTS13 are the cause of thrombotic thrombocytopenic purpura congenital (TTP) [MIM:274150]; also known as Upshaw-Schulman syndrome (USS). A hematologic disease characterized by hemolytic anemia with fragmentation of erythrocytes, thrombocytopenia, diffuse and non-focal neurologic findings, decreased renal function and fever.
  • 配列類似性Contains 2 CUB domains.
    Contains 1 disintegrin domain.
    Contains 1 peptidase M12B domain.
    Contains 8 TSP type-1 domains.
  • ドメインThe pro-domain is not required for folding or secretion and does not perform the common function of maintening enzyme latency.
    The spacer domain is necessary to recognize and cleave vWF. The C-terminal TSP type-1 and CUB domains may modulate this interaction.
  • 翻訳後修飾May contain a C-mannosylation site and O-fucosylation sites in the TSP type-1 domains.
    The precursor is processed by a furin endopeptidase which cleaves off the pro-domain.
  • 細胞内局在Secreted.
  • Information by UniProt

ADAMTS13 peptide (ab41249) 使用論文

ab41249 has not yet been referenced specifically in any publications.

Product Wall

Thank you very much. Unfortunately, I believe this peptide is not suitable for your intended experiments. The peptide ab41249 is a 36-amino acid oligopeptide with a mass of approximately 4.0 kDa. It does not have enzymatic activity. I am sorry I did n...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"