製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to ADAMTS13
  • 由来種
    Goat
  • アプリケーション
    適用あり: WB, IPmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Gorilla
  • 免疫原

    Synthetic peptide from a region between residue 825 and 875 of human ADAMTS13 (NP_620594.1)

  • ポジティブ・コントロール
    • Pooled normal human serum.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab72335 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
IP
  • 追加情報
    IP: 1-5 µg/µl serum.
    WB: 1/1,000 - 1/10,000. Predicted molecular weight: 154 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      Cleaves the vWF multimers in plasma into smaller forms.
    • 組織特異性
      Plasma. Expressed primarily in liver.
    • 関連疾患
      Defects in ADAMTS13 are the cause of thrombotic thrombocytopenic purpura congenital (TTP) [MIM:274150]; also known as Upshaw-Schulman syndrome (USS). A hematologic disease characterized by hemolytic anemia with fragmentation of erythrocytes, thrombocytopenia, diffuse and non-focal neurologic findings, decreased renal function and fever.
    • 配列類似性
      Contains 2 CUB domains.
      Contains 1 disintegrin domain.
      Contains 1 peptidase M12B domain.
      Contains 8 TSP type-1 domains.
    • ドメイン
      The pro-domain is not required for folding or secretion and does not perform the common function of maintening enzyme latency.
      The spacer domain is necessary to recognize and cleave vWF. The C-terminal TSP type-1 and CUB domains may modulate this interaction.
    • 翻訳後修飾
      May contain a C-mannosylation site and O-fucosylation sites in the TSP type-1 domains.
      The precursor is processed by a furin endopeptidase which cleaves off the pro-domain.
    • 細胞内局在
      Secreted.
    • Information by UniProt
    • 参照データベース
    • 別名
      • A disintegrin and metalloproteinase with thrombospondin motifs 13 antibody
      • A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 13 antibody
      • A disintegrin like and metalloprotease with thrombospondin type 1 motif 13 antibody
      • ADAM metallopeptidase with thrombospondin type 1 motif 13 antibody
      • ADAM TS antibody
      • ADAM-TS 13 antibody
      • ADAM-TS13 antibody
      • ADAMTS 13 antibody
      • ADAMTS-13 antibody
      • ADAMTS13 antibody
      • ADAMTS13 protein antibody
      • ATS13_HUMAN antibody
      • C9orf8 antibody
      • TTP antibody
      • Von Willebrand factor cleaving protease antibody
      • von Willebrand factor-cleaving protease antibody
      • vWF cleaving protease antibody
      • vWF CP antibody
      • vWF-cleaving protease antibody
      • vWF-CP antibody
      • vWFCP antibody
      see all

    画像

    • Immunoprecipitation/ Western Blot of ADAMTS13.
      Lane 1: ab72335.
      Lane 2: Control IgG.
      ab72335 at 1µg/ml for WB.
      Pooled normal human serum at 300µl/IP, 10% of IP loaded.
      Chemiluminescence with an exposure time of 30 seconds.
      Note: The antibody was conjugated to agarose to produce agarose immobilized antibody. Used at 35µg of antibody per IP.

    参考文献

    ab72335 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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