Anti-ADAMTS13 抗体 (ab72335)
Key features and details
- Goat polyclonal to ADAMTS13
- Suitable for: IP
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-ADAMTS13 antibody
ADAMTS13 一次抗体 製品一覧 -
製品の詳細
Goat polyclonal to ADAMTS13 -
由来種
Goat -
アプリケーション
適用あり: IPmore details -
種交差性
交差種: Human
交差が予測される動物種: Gorilla -
免疫原
Synthetic peptide from a region between residue 825 and 875 of human ADAMTS13 (NP_620594.1)
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ポジティブ・コントロール
- Pooled normal human serum.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7
Preservative: 0.09% Sodium azide
Constituents: 1.815% Tris, 1.764% Sodium citrate, 0.021% PBS -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab72335の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IP |
Use at an assay dependent concentration.
1-5 µg/µl serum. |
特記事項 |
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IP
Use at an assay dependent concentration. 1-5 µg/µl serum. |
ターゲット情報
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機能
Cleaves the vWF multimers in plasma into smaller forms. -
組織特異性
Plasma. Expressed primarily in liver. -
関連疾患
Defects in ADAMTS13 are the cause of thrombotic thrombocytopenic purpura congenital (TTP) [MIM:274150]; also known as Upshaw-Schulman syndrome (USS). A hematologic disease characterized by hemolytic anemia with fragmentation of erythrocytes, thrombocytopenia, diffuse and non-focal neurologic findings, decreased renal function and fever. -
配列類似性
Contains 2 CUB domains.
Contains 1 disintegrin domain.
Contains 1 peptidase M12B domain.
Contains 8 TSP type-1 domains. -
ドメイン
The pro-domain is not required for folding or secretion and does not perform the common function of maintening enzyme latency.
The spacer domain is necessary to recognize and cleave vWF. The C-terminal TSP type-1 and CUB domains may modulate this interaction. -
翻訳後修飾
May contain a C-mannosylation site and O-fucosylation sites in the TSP type-1 domains.
The precursor is processed by a furin endopeptidase which cleaves off the pro-domain. -
細胞内局在
Secreted. - Information by UniProt
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参照データベース
- Entrez Gene: 11093 Human
- Omim: 604134 Human
- SwissProt: Q76LX8 Human
- Unigene: 131433 Human
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別名
- A disintegrin and metalloproteinase with thrombospondin motifs 13 antibody
- A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 13 antibody
- A disintegrin like and metalloprotease with thrombospondin type 1 motif 13 antibody
see all
画像
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Immunoprecipitation/ Western Blot of ADAMTS13.
Lane 1: ab72335. Lane 2: Control IgG.
ab72335 at 1µg/ml for WB. Pooled normal human serum at 300µl/IP, 10% of IP loaded.
Chemiluminescence with an exposure time of 30 seconds. Note: The antibody was conjugated to agarose to produce agarose immobilized antibody. Used at 35µg of antibody per IP.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab72335 は論文での使用が確認できていません。