製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to ADAMTS13
  • 由来種
    Rabbit
  • アプリケーション
    適用あり: IPmore details
    適用なし: WB
  • 種交差性
    交差種: Human
    交差が予測される動物種: Rabbit, Horse, Guinea pig, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide corresponding to a region between residue 150 and 200 of human ADAMTS13 (according to NP_620594.1)

  • ポジティブ・コントロール
    • Human serum

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab72075 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IP Use at 1-5 µg/mg of lysate.
  • 追加情報
    Is unsuitable for WB.
  • ターゲット情報

    • 機能
      Cleaves the vWF multimers in plasma into smaller forms.
    • 組織特異性
      Plasma. Expressed primarily in liver.
    • 関連疾患
      Defects in ADAMTS13 are the cause of thrombotic thrombocytopenic purpura congenital (TTP) [MIM:274150]; also known as Upshaw-Schulman syndrome (USS). A hematologic disease characterized by hemolytic anemia with fragmentation of erythrocytes, thrombocytopenia, diffuse and non-focal neurologic findings, decreased renal function and fever.
    • 配列類似性
      Contains 2 CUB domains.
      Contains 1 disintegrin domain.
      Contains 1 peptidase M12B domain.
      Contains 8 TSP type-1 domains.
    • ドメイン
      The pro-domain is not required for folding or secretion and does not perform the common function of maintening enzyme latency.
      The spacer domain is necessary to recognize and cleave vWF. The C-terminal TSP type-1 and CUB domains may modulate this interaction.
    • 翻訳後修飾
      May contain a C-mannosylation site and O-fucosylation sites in the TSP type-1 domains.
      The precursor is processed by a furin endopeptidase which cleaves off the pro-domain.
    • 細胞内局在
      Secreted.
    • Information by UniProt
    • 参照データベース
    • 別名
      • A disintegrin and metalloproteinase with thrombospondin motifs 13 antibody
      • A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 13 antibody
      • A disintegrin like and metalloprotease with thrombospondin type 1 motif 13 antibody
      • ADAM metallopeptidase with thrombospondin type 1 motif 13 antibody
      • ADAM TS antibody
      • ADAM-TS 13 antibody
      • ADAM-TS13 antibody
      • ADAMTS 13 antibody
      • ADAMTS-13 antibody
      • ADAMTS13 antibody
      • ADAMTS13 protein antibody
      • ATS13_HUMAN antibody
      • C9orf8 antibody
      • TTP antibody
      • Von Willebrand factor cleaving protease antibody
      • von Willebrand factor-cleaving protease antibody
      • vWF cleaving protease antibody
      • vWF CP antibody
      • vWF-cleaving protease antibody
      • vWF-CP antibody
      • vWFCP antibody
      see all

    プロトコール

    参考文献

    ab72075 has not yet been referenced specifically in any publications.

    レビューと Q&A

    There are currently no Customer reviews or Questions for ab72075.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

    登録