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RabMAb

Anti-ADA 抗体 [EPR4438] (ab108352)

製品の概要

  • 製品名
    Anti-ADA antibody [EPR4438]
    ADA 一次抗体 製品一覧
  • 製品の詳細
    Rabbit monoclonal [EPR4438] to ADA
  • アプリケーション
    適用あり: WB, IP, ICCmore details
    適用なし: Flow Cyt or IHC-P
  • 種交差性
    交差種: Rat, Human
  • 免疫原

    A synthetic peptide corresponding to residues in Human ADA

  • ポジティブ・コントロール
    • Jurkat, fetal thymus, and rat kidney lysates
  • 特記事項

    This product is a recombinant rabbit monoclonal antibody.

    Mouse: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab108352 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000 - 1/10000. Predicted molecular weight: 41 kDa.
IP 1/10 - 1/100.
ICC 1/250 - 1/500.
  • 追加情報
    Is unsuitable for Flow Cyt or IHC-P.
  • ターゲット情報

    • 機能
      Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion.
    • 組織特異性
      Found in all tissues, occurs in large amounts in T-lymphocytes and, at the time of weaning, in gastrointestinal tissues.
    • 関連疾患
      Defects in ADA are the cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-negative/NK-cell-negative due to adenosine deaminase deficiency (ADASCID) [MIM:102700]. SCID refers to a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients with SCID present in infancy with recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. ADA-SCID is an autosomal recessive form accounting for about 50% of non-X-linked SCIDs. ADA deficiency has been diagnosed in chronically ill teenagers and adults (late or adult onset). Population and newborn screening programs have also identified several healthy individuals with normal immunity who have partial ADA deficiency.
    • 配列類似性
      Belongs to the adenosine and AMP deaminases family.
    • 細胞内局在
      Cell membrane. Cell junction. Cytoplasmic vesicle lumen. Cytoplasm. Colocalized with DPP4 at the cell junction in lymphocyte-epithelial cell adhesion.
    • Information by UniProt
    • 参照データベース
    • 別名
      • ada antibody
      • ADA_HUMAN antibody
      • ADA1 antibody
      • Adenosine aminohydrolase antibody
      • Adenosine deaminase antibody
      see all

    画像

    • All lanes : Anti-ADA antibody [EPR4438] (ab108352) at 1/1000 dilution

      Lane 1 : Jurkat cell lysate
      Lane 2 : Human fetal thymus lysate
      Lane 3 : Rat kidney tissue lysate

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 41 kDa
      Observed band size : 41 kDa

    参考文献

    ab108352 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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