Anti-ACVRL1 抗体 [RM0015-1B03] (ab51656)

製品の概要

  • 製品名Anti-ACVRL1 antibody [RM0015-1B03]
    ACVRL1 一次抗体 製品一覧
  • 製品の詳細
    Rat monoclonal [RM0015-1B03] to ACVRL1
  • 特異性ab51656 antibody recognizes mouse ACVRL1.
  • アプリケーション適用あり: WB, IHC-Frmore details
  • 種交差性
    交差種: Mouse
  • 免疫原

    Purified ALK1 extracellular domain (Mouse)

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab51656 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/200. Predicted molecular weight: 56 kDa.
IHC-Fr Use at an assay dependent dilution.

ターゲット情報

  • 機能On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well.
  • 関連疾患Defects in ACVRL1 are the cause of hereditary hemorrhagic telangiectasia type 2 (HHT2) [MIM:600376]; also known as Osler-Rendu-Weber syndrome 2 (ORW2). HHT2 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary, cerebral and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia.
  • 配列類似性Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 GS domain.
    Contains 1 protein kinase domain.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Activin A receptor antibody
    • Activin A receptor type II like 1 antibody
    • Activin A receptor, type II like kinase 1 antibody
    • Activin receptor like kinase 1 antibody
    • Activin receptor-like kinase 1 antibody
    • ACVL1_HUMAN antibody
    • ACVRL1 antibody
    • ACVRLK1 antibody
    • ALK-1 antibody
    • ALK1 antibody
    • HHT antibody
    • HHT2 antibody
    • ORW2 antibody
    • Osler Rendu Weber syndrome 2 antibody
    • Serine/threonine protein kinase receptor R3 antibody
    • Serine/threonine-protein kinase receptor R3 antibody
    • SKR3 antibody
    • TGF B superfamily receptor type I antibody
    • TGF-B superfamily receptor type I antibody
    • TSR-I antibody
    • TSR1 antibody
    see all

Anti-ACVRL1 antibody [RM0015-1B03] (ab51656) 使用論文

ab51656 has not yet been referenced specifically in any publications.

Product Wall

Abcam has not validated the combination of species/application used in this Abreview.
Application Immunohistochemistry (PFA perfusion fixed frozen sections)
Blocking step Serum as blocking agent for 30 minute(s) · Concentration: 5% · Temperature: 25°C
Antigen retrieval step Enzymatic
Sample Mouse Tissue sections (Brain)
Specification Brain
Permeabilization Yes - Triton 0.01%
Fixative Paraformaldehyde
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投稿 Sep 09 2013

Application Immunohistochemistry (Frozen sections)
Blocking step Serum as blocking agent for 30 minute(s) · Concentration: 5% · Temperature: 25°C
Sample Mouse Tissue sections (Brain)
Specification Brain
Permeabilization No
Fixative Paraformaldehyde
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投稿 Aug 24 2013

Abcam has not validated the combination of species/application used in this Abreview.
Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Blocking step Serum as blocking agent for 30 minute(s) · Concentration: 5% · Temperature: 25°C
Antigen retrieval step Other
Sample Mouse Tissue sections (Brain)
Specification Brain
Permeabilization Yes - Tween20
Fixative Paraformaldehyde
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Verified customer

投稿 Aug 23 2013

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"