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RabMAb

Anti-ACVRL1 抗体 [EPR4074] (ab108207)

製品の概要

  • 製品名
    Anti-ACVRL1 antibody [EPR4074]
    ACVRL1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit monoclonal [EPR4074] to ACVRL1
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) corresponding to Human ACVRL1 aa 450 to the C-terminus.
    Database link: P37023
    (Peptide available as ab190772)

  • ポジティブ・コントロール
    • JAR, Daudi or Jurkat cell lysate
  • 特記事項

    This product is a recombinant rabbit monoclonal antibody.

    We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result of this work we are pleased to now offer this antibody in purified format. We are in the process of updating our datasheets. The purified format is designated ‘PUR’ on our product labels. If you have any questions regarding this update, please contact our Scientific Support team.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab108207 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000 - 1/10000. Predicted molecular weight: 56 kDa.

ターゲット情報

  • 機能
    On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well.
  • 関連疾患
    Defects in ACVRL1 are the cause of hereditary hemorrhagic telangiectasia type 2 (HHT2) [MIM:600376]; also known as Osler-Rendu-Weber syndrome 2 (ORW2). HHT2 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary, cerebral and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia.
  • 配列類似性
    Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 GS domain.
    Contains 1 protein kinase domain.
  • 細胞内局在
    Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Activin A receptor antibody
    • Activin A receptor type II like 1 antibody
    • Activin A receptor, type II like kinase 1 antibody
    • Activin receptor like kinase 1 antibody
    • Activin receptor-like kinase 1 antibody
    • ACVL1_HUMAN antibody
    • ACVRL1 antibody
    • ACVRLK1 antibody
    • ALK-1 antibody
    • ALK1 antibody
    • HHT antibody
    • HHT2 antibody
    • ORW2 antibody
    • Osler Rendu Weber syndrome 2 antibody
    • Serine/threonine protein kinase receptor R3 antibody
    • Serine/threonine-protein kinase receptor R3 antibody
    • SKR3 antibody
    • TGF B superfamily receptor type I antibody
    • TGF-B superfamily receptor type I antibody
    • TSR-I antibody
    • TSR1 antibody
    see all

画像

  • All lanes : Anti-ACVRL1 antibody [EPR4074] (ab108207) at 1/1000 dilution (purified)

    Lane 1 : mouse brain lysate
    Lane 2 : mouse kidney lysate
    Lane 3 : rat brain lysate
    Lane 4 : rat kidney lysate

    Lysates/proteins at 20 µg per lane.

    Secondary
    HRP goat anti-rabbit IgG (H+L) at 1/50000 dilution

    Predicted band size : 56 kDa
    Observed band size : 56 kDa

    Blocking buffer: 5% NFDM/TBST
    Dilution buffer: 5% NFDM/TBST

  • All lanes : Anti-ACVRL1 antibody [EPR4074] (ab108207) at 1/1000 dilution (purified)

    Lane 1 : JAR cell lysate
    Lane 2 : Daudi cell lysate
    Lane 3 : Jurkat cell lysate

    Lysates/proteins at 20 µg per lane.

    Secondary
    HRP goat anti-rabbit IgG (H+L) at 1/50000 dilution

    Predicted band size : 56 kDa
    Observed band size : 56 kDa

    Blocking buffer: 5% NFDM/TBST
    Dilution buffer: 5% NFDM/TBST

  • All lanes : Anti-ACVRL1 antibody [EPR4074] (ab108207) at 1/1000 dilution (unpurified)

    Lane 1 : JAR cell lysate
    Lane 2 : Daudi cell lysate
    Lane 3 : Jurkat cell lysate

    Lysates/proteins at 10 µg per lane.


    Predicted band size : 56 kDa

プロトコール

参考文献

ab108207 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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