製品の概要

  • 製品名Anti-ACVRL1 antibody
    ACVRL1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to ACVRL1
  • アプリケーション適用あり: ELISA, WB, IHC-Pmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    A KLH conjugated synthetic peptide selected from the sequence of human ACVRL1 within aa 1-100 (N-terminal).

  • ポジティブ・コントロール
    • Mouse heart tissue lysate and hepatocarcinoma tissue

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab37807 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/1000.
WB 1/100 - 1/500. Detects a band of approximately 56 kDa (predicted molecular weight: 56 kDa).
IHC-P 1/50 - 1/100.

ターゲット情報

  • 機能On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well.
  • 関連疾患Defects in ACVRL1 are the cause of hereditary hemorrhagic telangiectasia type 2 (HHT2) [MIM:600376]; also known as Osler-Rendu-Weber syndrome 2 (ORW2). HHT2 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary, cerebral and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia.
  • 配列類似性Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 GS domain.
    Contains 1 protein kinase domain.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Activin A receptor antibody
    • Activin A receptor type II like 1 antibody
    • Activin A receptor, type II like kinase 1 antibody
    • Activin receptor like kinase 1 antibody
    • Activin receptor-like kinase 1 antibody
    • ACVL1_HUMAN antibody
    • ACVRL1 antibody
    • ACVRLK1 antibody
    • ALK-1 antibody
    • ALK1 antibody
    • HHT antibody
    • HHT2 antibody
    • ORW2 antibody
    • Osler Rendu Weber syndrome 2 antibody
    • Serine/threonine protein kinase receptor R3 antibody
    • Serine/threonine-protein kinase receptor R3 antibody
    • SKR3 antibody
    • TGF B superfamily receptor type I antibody
    • TGF-B superfamily receptor type I antibody
    • TSR-I antibody
    • TSR1 antibody
    see all

Anti-ACVRL1 antibody 画像

  • Anti-ACVRL1 antibody (ab37807) at 1/100 dilution + mouse heart tissue lysate

    Predicted band size : 56 kDa
    Observed band size : 56 kDa
    Additional bands at : 25 kDa,45 kDa,70 kDa. We are unsure as to the identity of these extra bands.
  • ab37807 at a 1/50 dilution detecting ACVRL1 expression in human hepatocarcinoma tissue (a peroxidase-conjugated secondary antibody, followed by AEC staining was used).

    These data demonstrate the suitability of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-ACVRL1 antibody (ab37807) 使用論文

ab37807 has not yet been referenced specifically in any publications.

Product Wall

Thank you for calling.

As we discussed, I think you should try a different antibody, but no others have been tested for IHC on mouse tissue. I think ab68703 may be a good choice, even though it has not been tested for reactivity with mouse t...

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Thank you for contacting us. While I am unaware of any references describingACVRL1 expression in tumors, the human protein atlas (linked below) does show that "distinct cytoplasmic staining with a granular pattern was observed in thyroid cancers, ...

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