Anti-Activin Receptor Type IA 抗体 (ab117242)

製品の概要

  • 製品名Anti-Activin Receptor Type IA antibody
    Activin Receptor Type IA 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Activin Receptor Type IA
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic peptide, corresponding to a region within amino acids 475-509 of Human Activin Receptor Type IA (NP_001096.1).

  • ポジティブ・コントロール
    • Human Skeletal Muscle Vessel tissue.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab117242 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 3 - 5 µg/ml. Predicted molecular weight: 57 kDa.
IHC-P Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis.
  • 組織特異性Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells.
  • 関連疾患Defects in ACVR1 are a cause of fibrodysplasia ossificans progressiva (FOP) [MIM:135100]. FOP is a rare autosomal dominant disorder of skeletal malformations and progressive extraskeletal ossification. Heterotopic ossification in FOP begins in childhood and can be induced by trauma or may occur without warning. Bone formation is episodic and progressive, leading to extra-articular ankylosis of all major joints of the axial and appendicular skeleton, rendering movement impossible.
  • 配列類似性Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 GS domain.
    Contains 1 protein kinase domain.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Activin A receptor type I antibody
    • Activin A receptor type II like kinase 2 antibody
    • Activin receptor type I antibody
    • Activin receptor type-1 antibody
    • Activin receptor-like kinase 2 antibody
    • ACTR-I antibody
    • ACTRI antibody
    • Acvr1 antibody
    • ACVR1_HUMAN antibody
    • ACVR1A antibody
    • ACVRLK2 antibody
    • ALK 2 antibody
    • ALK-2 antibody
    • ALK2 antibody
    • FOP antibody
    • Hydroxyalkyl protein kinase antibody
    • Serine/threonine-protein kinase receptor R1 antibody
    • SKR1 antibody
    • TGF-B superfamily receptor type I antibody
    • TGFB superfamily receptor type I antibody
    • TSR-I antibody
    • TSRI antibody
    see all

Anti-Activin Receptor Type IA antibody 画像

  • ab117242, at 10 µg/ml, staining Activin Receptor Type IA in Formalin-fixed, Paraffin-embedded Human Skeletal muscle vessel tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-Activin Receptor Type IA antibody (ab117242) 使用論文

ab117242 has not yet been referenced specifically in any publications.

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