Anti-Activin A 抗体 [MM0074-7L18] (ab89307)
Key features and details
- Mouse monoclonal [MM0074-7L18] to Activin A
- Suitable for: Neutralising, WB
- Reacts with: Rat, Human
- Isotype: IgG1
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-Activin A antibody [MM0074-7L18] -
製品の詳細
Mouse monoclonal [MM0074-7L18] to Activin A -
由来種
Mouse -
アプリケーション
適用あり: Neutralising, WBmore details -
種交差性
交差種: Rat, Human -
免疫原
Recombinant full length protein corresponding to Human Activin A. Human recombinant Pro-Activin-A
Database link: P08476 -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
Constituent: PBS -
Concentration information loading...
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精製度
Protein G purified -
ポリ/モノ
モノクローナル -
クローン名
MM0074-7L18 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab89307の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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Neutralising |
Use at an assay dependent concentration.
(1) Activin A can induce hemoglobin expression in the K562 human chronic myelogenous leukemia cell line. (2) Anti-Activin antibody can neutralize Activin A induced hemoglobin expression in a dose dependent manner. ED 50 is approximately between 30-60ng/mL in the presence of 5ng/mL Recombinant Human Activin A. |
|
WB | (2) |
Use at an assay dependent concentration.
|
特記事項 |
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Neutralising
Use at an assay dependent concentration. (1) Activin A can induce hemoglobin expression in the K562 human chronic myelogenous leukemia cell line. (2) Anti-Activin antibody can neutralize Activin A induced hemoglobin expression in a dose dependent manner. ED 50 is approximately between 30-60ng/mL in the presence of 5ng/mL Recombinant Human Activin A. |
WB
Use at an assay dependent concentration. |
ターゲット情報
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機能
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. -
配列類似性
Belongs to the TGF-beta family. -
細胞内局在
Secreted. - Information by UniProt
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参照データベース
- Entrez Gene: 3624 Human
- Entrez Gene: 29200 Rat
- Omim: 147290 Human
- SwissProt: P08476 Human
- SwissProt: P18331 Rat
- Unigene: 583348 Human
- Unigene: 9874 Rat
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製品の状態
Activin A is a homodimer of beta-A. -
別名
- Activin A antibody
- Activin beta A chain antibody
- Activin beta-A chain antibody
see all
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (6)
ab89307 は 6 報の論文で使用されています。
- Fei ZY et al. Analysis of bacterial spectrum, activin A, and CD64 in chronic obstructive pulmonary disease patients complicated with pulmonary infections. World J Clin Cases 10:2382-2392 (2022). PubMed: 35434072
- Wang JQ et al. Knockdown of microRNA-17-5p Enhances the Neuroprotective Effect of Act A/Smads Signal Loop After Ischemic Injury. Neurochem Res 44:1807-1817 (2019). PubMed: 31093905
- Castillero E et al. Structural and functional cardiac profile after prolonged duration of mechanical unloading: potential implications for myocardial recovery. Am J Physiol Heart Circ Physiol 315:H1463-H1476 (2018). PubMed: 30141986
- Tsigkou A et al. Expression Levels of Myostatin and Matrix Metalloproteinase 14 mRNAs in Uterine Leiomyoma are Correlated With Dysmenorrhea. Reprod Sci 22:1597-602 (2015). PubMed: 26138721
- Karve TM et al. BRCA1 regulates follistatin function in ovarian cancer and human ovarian surface epithelial cells. PLoS One 7:e37697 (2012). WB ; Human . PubMed: 22685544
- Lonardo E et al. Pancreatic stellate cells form a niche for cancer stem cells and promote their self-renewal and invasiveness. Cell Cycle 11:1282-90 (2012). PubMed: 22421149