製品の概要

  • 製品名
  • 製品の詳細
    Mouse monoclonal to ACK1
  • アプリケーション
    適用あり: ELISA, WBmore details
  • 種交差性
    交差種: Drosophila melanogaster
  • 免疫原

    ACK peptides.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab90323 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA Use at an assay dependent dilution.
WB Use at an assay dependent dilution. Predicted molecular weight: 114 kDa.

ターゲット情報

  • 機能
    Non-receptor tyrosine kinase that regulates the activity of a number of proteins by tyrosine phosphorylation especially proteins critical for cell survival, cell growth, and proliferation. Activates AKT1 by phosphorylating it on 'Tyr-176' resulting in its activation. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' and promotes its recruitment to the androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR. Participates in clathrin-mediated endocytosis. May be involved both in adult synaptic function and plasticity and in brain development.
  • 組織特異性
    The Tyr-284 phosphorylated form shows a significant increase in expression in breast cancers during the progressive stages i.e. normal to hyperplasia (ADH), ductal carcinoma in situ (DCIS), invasive ductal carcinoma (IDC) and lymph node metastatic (LNMM) stages. It also shows a significant increase in expression in prostate cancers during the progressive stages.
  • 配列類似性
    Belongs to the protein kinase superfamily. Tyr protein kinase family.
    Contains 1 CRIB domain.
    Contains 1 protein kinase domain.
    Contains 1 SH3 domain.
    Contains 1 UBA domain.
  • ドメイン
    The EBD (EGFR-binding domain) domain is necessary for interaction with EGFR.
    The SAM-like domain is necessary for NEDD4-mediated ubiquitination. Promotes membrane localization and dimerization to allow for autophosphorylation.
    The UBA domain binds both poly- and mono-ubiquitin.
  • 翻訳後修飾
    Autophosphorylation regulates kinase activity. Phosphorylation on Tyr-518 is required for interaction with SRC.
    Ubiquitinated by NEDD4. Its EGF-induced degradation is EGFR activation-dependent and is processed by lysosomes, not proteasomes.
  • 細胞内局在
    Cell membrane. Nucleus. Endosome. Cell junction > adherens junction. Cytoplasmic vesicle membrane. The Tyr-284 phosphorylated form is expressed both in the membrane and nucleus. Co-localizes with EGFR on the endosomes.
  • Information by UniProt
  • 別名
    • Acetate kinase 1 antibody
    • Acetokinase 1 antibody
    • ACK 1 antibody
    • ACK antibody
    • ACK-1 antibody
    • ACK1 antibody
    • ACK1_HUMAN antibody
    • Activated Cdc42 associated kinase 1 antibody
    • Activated CDC42 kinase 1 antibody
    • Activated p21cdc42Hs kinase antibody
    • FLJ44758 antibody
    • FLJ45547 antibody
    • p21cdc42Hs antibody
    • TNK 2 antibody
    • TNK2 antibody
    • Tyrosine kinase non receptor 2 antibody
    • Tyrosine kinase non receptor protein 2 antibody
    • Tyrosine kinase non-receptor protein 2 antibody
    see all

プロトコール

参考文献

ab90323 has not yet been referenced specifically in any publications.

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