, corresponding to amino acids 994-1009 of Human Acinus L, 267 to 282 of human Acinus S’, or 236 to 251 of human Acinus S, which are identical to those of mouse Acinus. The selected antigenic sequence is located near the N-terminus of active peptide p17.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use at an assay dependant dilution. Detects a band of approximately 220 kDa (predicted molecular weight: 151 kDa). Can be blocked with Acinus (N-term) peptide (human)
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Induces apoptotic chromatin condensation after activation by CASP3.
Contains 1 SAP domain.
Undergoes proteolytic cleavage; the processed form is active, contrary to the uncleaved form.