製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to ACADL
  • 由来種
    Rabbit
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Human
    交差が予測される動物種: Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Pig
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 288-337 (LPQERLLIAD VAISASEFMF EETRNYVKQR KAFGKTVAHL QTVQHKLAEL) of human ACADL (NP_001599).

  • ポジティブ・コントロール
    • Placental lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab82853 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 48 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • パスウェイ
    Lipid metabolism; mitochondrial fatty acid beta-oxidation.
  • 関連疾患
    Defects in ACADL are a cause of acyl-CoA dehydrogenase very long-chain deficiency (ACADVLD) [MIM:201475]. An inborn error of mitochondrial fatty acid beta-oxidation which leads to impaired long-chain fatty acid beta-oxidation. It is clinically heterogeneous, with three major phenotypes: a severe childhood form characterized by early onset, high mortality and high incidence of cardiomyopathy; a milder childhood form with later onset, characterized by hypoketotic hypoglycemia, low mortality and rare cardiomyopathy; an adult form, with isolated skeletal muscle involvement, rhabdomyolysis and myoglobinuria, usually triggered by exercise or fasting.
  • 配列類似性
    Belongs to the acyl-CoA dehydrogenase family.
  • 細胞内局在
    Mitochondrion matrix.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ACAD4 antibody
    • ACADL antibody
    • ACADL_HUMAN antibody
    • Acyl Coenzyme A dehydrogenase long chain antibody
    • Acyl-CoA dehydrogenase long chain antibody
    • FLJ94052 antibody
    • LCAD antibody
    • Long chain acyl CoA dehydrogenase antibody
    • Long-chain specific acyl-CoA dehydrogenase, mitochondrial antibody
    see all

画像

  • Anti-ACADL antibody (ab82853) at 1 µg/ml (in 5% skim milk / PBS buffer) + placental lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size: 48 kDa
    Observed band size: 40 kDa (why is the actual band size different from the predicted?)
    Additional bands at: 24 kDa. We are unsure as to the identity of these extra bands.



    Gel Concentration 12%

プロトコール

参考文献

This product has been referenced in:
  • LaBarge SA  et al. p300 is not required for metabolic adaptation to endurance exercise training. FASEB J 30:1623-33 (2016). Read more (PubMed: 26712218) »
  • Mells JE  et al. Glp-1 analog, liraglutide, ameliorates hepatic steatosis and cardiac hypertrophy in C57BL/6J mice fed a Western diet. Am J Physiol Gastrointest Liver Physiol 302:G225-35 (2012). WB ; Mouse . Read more (PubMed: 22038829) »

See all 2 Publications for this product

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