Anti-ABCD1 抗体 (ab77364)

製品の概要

• 製品名
  Anti-ABCD1 antibody
  ABCD1 一次抗体 製品一覧
• 製品の詳細
  Goat polyclonal to ABCD1
• アプリケーション
  適用あり: WB, ELISAmore details
• 種交差性
  交差種: Human
  交差が予測される動物種: Horse, Dog
• 免疫原

  Synthetic peptide:

  EDMQRKGYSEQD

  , corresponding to amino acids 564-575 of Human ABCD1 (NP_000024.2)

  Run BLAST with Run BLAST with
• ポジティブ･コントロール
  • Human brain (cerebellum) lysates

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• バッファー
  Preservative: 0.02% Sodium Azide
  Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
• Concentration information loading...
• 精製度
  Immunogen affinity purified
• 特記事項（精製）
  Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• ポリ/モノ
  ポリクローナル
• アイソタイプ
  IgG
• 研究分野
  • Tags & Cell Markers
  • Subcellular Markers
  • Organelles
  • Peroxisome

  • Signal Transduction
  • Protein Trafficking
  • Organelle Proteins

  • Signal Transduction
  • Metabolism
  • Lipid metabolism

  • Cancer
  • Cancer Metabolism
  • Metabolic signaling pathway
  • Metabolism of lipids and lipoproteins

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Lipid and lipoprotein metabolism
  • Lipid metabolism

  • Metabolism
  • Types of disease
  • Cancer

関連製品

• Compatible Secondaries
  • Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (ab150129)
  • Donkey Anti-Goat IgG H&L (HRP) (ab205723)

アプリケーション

ターゲット情報

• 機能
  Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity.
• 関連疾患
  Defects in ABCD1 are the cause of adrenoleukodystrophy X-linked (X-ALD) [MIM:300100]. X-ALD is a peroxisomal metabolic disorder characterized by progressive multifocal demyelination of the central nervous system and by peripheral adrenal insufficiency (Addison disease). It results in mental deterioration, corticospinal tract dysfunction, and cortical blindness. Different clinical manifestations exist like: cerebral childhood ALD (CALD), adult cerebral ALD (ACALD), adrenomyeloneuropathy (AMN) and 'Addison disease only' (ADO) phenotype.
  Note=The promoter region of ABCD1 is deleted in the chromosome Xq28 deletion syndrome which involves ABCD1 and the neighboring gene BCAP31.
• 配列類似性
  Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
  Contains 1 ABC transmembrane type-1 domain.
  Contains 1 ABC transporter domain.
• 細胞内局在
  Peroxisome membrane.

• Target information above from: UniProt accession P33897 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 215 Human
  • Omim: 300371 Human
  • SwissProt: P33897 Human
  • Unigene: 159546 Human
• 別名
  • ABC42 antibody
  • Abcd1 antibody
  • ABCD1_HUMAN antibody

  • Adrenoleukodystrophy protein antibody
  • ALD antibody
  • Aldgh antibody
  • ALDP antibody
  • AMN antibody
  • ATP binding cassette, sub family D (ALD), member 1 antibody
  • ATP-binding cassette sub-family D member 1 antibody
  • OTTHUMP00000025960 antibody
  • OTTMUSP00000019283 antibody
  • RGD1562128 antibody
  • RP23 373N8.2 antibody
  • X linked adrenoleukodystrophy (ALD) gene homolog antibody

  see all

プロトコール

• Western blot protocols