製品の概要

  • 製品名Anti-ABCC9 antibody
    ABCC9 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to ABCC9
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Goat, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Pig, Caenorhabditis elegans, Drosophila melanogaster, Zebrafish
  • 免疫原

    Synthetic peptide designed within residues: AVVTEGGENF SVGQRQLFCL ARAFVRKSSI LIMDEATASI DMATENILQK, corresponding to internal sequence amino acids 1440 - 1489 of Human ABCC9 (NP_005682)

  • ポジティブ・コントロール
    • 721_B cell lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab84299 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 174 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.
  • 関連疾患Defects in ABCC9 are the cause of cardiomyopathy dilated type 1O (CMD1O) [MIM:608569]; also known as dilated cardiomyopathy with ventricular tachycardia. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
    Defects in ABCC9 are the cause of familial atrial fibrillation type 12 (ATFB12) [MIM:614050]. ATFB12 is a familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure.
  • 配列類似性Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
    Contains 2 ABC transmembrane type-1 domains.
    Contains 2 ABC transporter domains.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ABC37 antibody
    • abcC9 antibody
    • ABCC9_HUMAN antibody
    • AI414027 antibody
    • AI449286 antibody
    • ATFB12 antibody
    • ATP-binding cassette sub-family C member 9 antibody
    • ATP-binding cassette transporter sub-family C member 9 antibody
    • ATP-binding cassette, sub-family C (CFTR/MRP), member 9 antibody
    • CANTU antibody
    • CMD1O antibody
    • FLJ36852 antibody
    • Sulfonylurea receptor 2 antibody
    • Sulfonylurea-binding protein 2 antibody
    • SUR2 antibody
    • SUR2A antibody
    • SUR2B antibody
    see all

Anti-ABCC9 antibody 画像



  • Predicted band size : 174 kDa
    Western blot analysis of 10µg SUR1 KO (lane 1) 10µg WT (lane 2) 0.1µg SUR1 overexpressing (lane 3) mouse ventricle lysates and 10µg cannine ventricle lysate (lane 4) labeling ABCC9 with ab84299 at 1:1000. A HRP-conjugated anti-rabbit (1:2000) was used as the secondary antibody.
  • Anti-ABCC9 antibody (ab84299) at 1 µg/ml + 721_B cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 174 kDa
    Observed band size : 174 kDa
    Additional bands at : 45 kDa,70 kDa. We are unsure as to the identity of these extra bands.

Anti-ABCC9 antibody (ab84299) 使用論文

ab84299 has not yet been referenced specifically in any publications.

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