製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to ABCB7
  • 特異性
    This antibody reacts with ABCB7
  • アプリケーション
    適用あり: IHC-P, ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide corresponding to Human ABCB7 aa 733-747 conjugated to Keyhole Limpet Haemocyanin (KLH).

  • ポジティブ・コントロール
    • Thymus tissue

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab65149 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use a concentration of 10 µg/ml.
ELISA 1/10 - 1/1000.

ターゲット情報

  • 機能
    Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins.
  • 関連疾患
    Defects in ABCB7 are the cause of X-linked sideroblastic anemia with ataxia (ASAT) [MIM:301310]. ASAT is a recessive disorder characterized by an infantile to early childhood onset of nonprogressive cerebellar ataxia and mild anemia with hypochromia and microcytosis.
  • 配列類似性
    Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
    Contains 1 ABC transmembrane type-1 domain.
    Contains 1 ABC transporter domain.
  • 細胞内局在
    Mitochondrion inner membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ABC transporter 7 protein antibody
    • ABC7 antibody
    • Abcb7 antibody
    • ABCB7_HUMAN antibody
    • ASAT antibody
    • Atm1p antibody
    • ATP binding cassette 7 antibody
    • ATP binding cassette sub family B (MDR/TAP) member 7 antibody
    • ATP binding cassette sub family B member 7 antibody
    • ATP binding cassette sub family B member 7 mitochondrial antibody
    • ATP binding cassette transporter 7 antibody
    • ATP-binding cassette sub-family B member 7 antibody
    • ATP-binding cassette transporter 7 antibody
    • EST140535 antibody
    • MDR7 antibody
    • mitochondrial antibody
    • Multidrug resistance protein 7 antibody
    • P-glycoprotein 7 antibody
    • PGP7 antibody
    see all

画像

  • ab65149 at 10µg/ml staining ABCB7 in Formalin-Fixed Paraffin-Embedded human thymus tissue.

プロトコール

参考文献

This product has been referenced in:
  • Nikpour M  et al. The transporter ABCB7 is a mediator of the phenotype of acquired refractory anemia with ring sideroblasts. Leukemia 27:889-896 (2013). Read more (PubMed: 23070040) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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