製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to ABCB5
  • アプリケーション
    適用あり: ELISA, WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    KLH conjugated synthetic peptide selected from the N terminal region of human ABCB5

  • ポジティブ・コントロール
    • K562 cell line lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab80108 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/1000.
WB 1/50 - 1/100. Predicted molecular weight: 90 kDa.

ターゲット情報

  • 機能
    Plasma membrane transporter able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Responsible for the resistance to doxorubicin of a subset of malignant melanomas.
  • 組織特異性
    Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Also expressed in several malignant tissues.
  • 配列類似性
    Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
    Contains 1 ABC transmembrane type-1 domain.
    Contains 2 ABC transporter domains.
  • 細胞内局在
    Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ABCB 5 antibody
    • ABCB5 antibody
    • ABCB5 P-gp antibody
    • ABCB5_HUMAN antibody
    • ABCB5alpha antibody
    • ABCB5beta antibody
    • ATP binding cassette protein antibody
    • ATP binding cassette sub family B (MDR/TAP) member 5 antibody
    • ATP binding cassette sub family B member 5 antibody
    • ATP-binding cassette sub-family B member 5 antibody
    • EST422562 antibody
    • P glycoprotein ABCB5 antibody
    • P-glycoprotein ABCB5 antibody
    see all

画像

  • Anti-ABCB5 antibody (ab80108) at 1/50 dilution + K562 cell line lysates at 35 µg

    Predicted band size : 90 kDa
    Observed band size : 90 kDa

プロトコール

参考文献

This product has been referenced in:
  • Keniya MV  et al. Drug resistance is conferred on the model yeast Saccharomyces cerevisiae by expression of full-length melanoma-associated human ATP-binding cassette transporter ABCB5. Mol Pharm 11:3452-62 (2014). Read more (PubMed: 25115303) »

See 1 Publication for this product

レビューと Q&A

Thank you for contacting us.
The immunogen sequence is in both the beta and full length version of the gene. It will therefore recognize both versions of the gene.
Ab80108 antibody is generated from rabbits immunized with a KLH conjugated syn...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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