Anti-Plakophilin 2/PKP2 抗体 (ab189323)
Key features and details
- Goat polyclonal to Plakophilin 2/PKP2
- Suitable for: WB, IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
製品の概要
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製品名
Anti-Plakophilin 2/PKP2 antibody
Plakophilin 2/PKP2 一次抗体 製品一覧 -
製品の詳細
Goat polyclonal to Plakophilin 2/PKP2 -
由来種
Goat -
アプリケーション
適用あり: WB, IHC-Pmore details -
種交差性
交差種: Mouse, Human
交差が予測される動物種: Rabbit, Horse, Hamster, Cow, Dog, Gorilla, Bat -
免疫原
Synthetic peptide corresponding to Human Plakophilin 2/PKP2 aa 100-200 (internal sequence) (Cysteine residue). (NP_001005242.2; NP_004563.2).
Database link: Q99959 -
ポジティブ・コントロール
- Human prostate tissue; Mouse and Rat heart lysates.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
バッファー
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 99% Tris buffered saline, 0.5% BSA -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab189323の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 97 kDa.
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IHC-P |
Use a concentration of 3.75 µg/ml.
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特記事項 |
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WB
Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 97 kDa. |
IHC-P
Use a concentration of 3.75 µg/ml. |
ターゲット情報
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機能
May play a role in junctional plaques. -
組織特異性
Detected in heart right ventricle (at protein level). Widely expressed. Found at desmosomal plaques in simple and stratified epithelia and in non-epithelial tissues such as myocardium and lymph node follicles. In most stratified epithelia found in the desmosomes of the basal cell layer and seems to be absent from suprabasal strata. -
関連疾患
Familial arrhythmogenic right ventricular dysplasia 9 -
配列類似性
Belongs to the beta-catenin family.
Contains 8 ARM repeats. -
細胞内局在
Nucleus. Cell junction > desmosome. Nuclear and associated with desmosomes. - Information by UniProt
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参照データベース
- Entrez Gene: 537784 Cow
- Entrez Gene: 486613 Dog
- Entrez Gene: 101150898 Gorilla
- Entrez Gene: 101830795 Hamster
- Entrez Gene: 100070065 Horse
- Entrez Gene: 5318 Human
- Entrez Gene: 67451 Mouse
- Entrez Gene: 100347738 Rabbit
see all -
別名
- ARVD 9 antibody
- ARVD9 antibody
- PKP 2 antibody
see all
画像
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (3)
ab189323 は 3 報の論文で使用されています。
- Gross A et al. Desmoplakin Maintains Transcellular Keratin Scaffolding and Protects From Intestinal Injury. Cell Mol Gastroenterol Hepatol 13:1181-1200 (2022). PubMed: 34929421
- Vallverdú-Prats M et al. Premature Termination Codon in 5' Region of Desmoplakin and Plakoglobin Genes May Escape Nonsense-Mediated Decay through the Reinitiation of Translation. Int J Mol Sci 23:N/A (2022). PubMed: 35054841
- Zhang Z et al. Cardiac-Specific Caveolin-3 Overexpression Prevents Post-Myocardial Infarction Ventricular Arrhythmias by Inhibiting Ryanodine Receptor-2 Hyperphosphorylation. Cardiology 145:136-147 (2020). PubMed: 32007997