Anti-Cytokeratin 5 + 6 抗体 [D5/16 B4] (ab17133)
Key features and details
- Mouse monoclonal [D5/16 B4] to Cytokeratin 5 + 6
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG1
製品の概要
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製品名
Anti-Cytokeratin 5 + 6 antibody [D5/16 B4] -
製品の詳細
Mouse monoclonal [D5/16 B4] to Cytokeratin 5 + 6 -
由来種
Mouse -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Human -
免疫原
Full length native protein (purified) corresponding to Human Cytokeratin 5 + 6.
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ポジティブ・コントロール
- IHC-P: Human tonsil tissue.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.3
Preservative: 0.05% Sodium azide
Constituent: 1% BSA -
Concentration information loading...
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精製度
Protein G purified -
ポリ/モノ
モノクローナル -
クローン名
D5/16 B4 -
アイソタイプ
IgG1 -
軽鎖の種類
kappa -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab17133の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-P | (2) |
1/25 - 1/50.
Pretreat tissue with citrate buffer pH 6. Incubate with primary antibody for 30 minutes at room temperature. |
特記事項 |
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IHC-P
1/25 - 1/50. Pretreat tissue with citrate buffer pH 6. Incubate with primary antibody for 30 minutes at room temperature. |
ターゲット情報
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関連性
Cytokeratin 5 (58 kD) is a high molecular weight, basic type of cytokeratin expressed in basal, the intermediate and the superficial cell layers of stratified epithelia as well as transitional epithelia, complex epithelia and in mesothelial cells and mesothelioma. Cytokeratin 6 (56 kD) is also a high molecular weight, basic type cytokeratin expressed by proliferating squamous epithelium often paired with Cytokeratin 16. -
細胞内局在
Cytoplasmic -
参照データベース
- Entrez Gene: 3852 Human
- Entrez Gene: 3853 Human
- Entrez Gene: 3854 Human
- Omim: 148040 Human
- SwissProt: P02538 Human
- SwissProt: P04259 Human
- SwissProt: P13647 Human
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別名
- Cytokeratin 5 antibody
- Cytokeratin 6A antibody
- Cytokeratin 6B antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (12)
ab17133 は 12 報の論文で使用されています。
- Xu Y et al. Immunosuppressive tumor-associated macrophages expressing interlukin-10 conferred poor prognosis and therapeutic vulnerability in patients with muscle-invasive bladder cancer. J Immunother Cancer 10:N/A (2022). PubMed: 35338085
- Ding RB et al. Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics. Nat Commun 12:3046 (2021). PubMed: 34031426
- Al-Khalaf HH et al. Senescent Breast Luminal Cells Promote Carcinogenesis through Interleukin-8-Dependent Activation of Stromal Fibroblasts. Mol Cell Biol 39:N/A (2019). PubMed: 30397077
- Vahidnezhad H et al. Biallelic KRT5 mutations in autosomal recessive epidermolysis bullosa simplex, including a complete human keratin 5 "knock-out". Matrix Biol 83:48-59 (2019). PubMed: 31302245
- Ota T et al. Validity of using immunohistochemistry to predict treatment outcome in patients with non-small cell lung cancer not otherwise specified. J Cancer Res Clin Oncol 145:2495-2506 (2019). PubMed: 31494736