Compound 55, DOT1L Inhibitor, DOT1L inhibitor (ab145525)
Key features and details
- Highly potent, selective DOT1L inhibitor
- CAS Number: 1381761-52-9
- Purity: > 98%
- Soluble in water to 50 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Compound 55, DOT1L Inhibitor, DOT1L inhibitor -
製品の詳細
Highly potent, selective DOT1L inhibitor -
生理活性の詳細
Highly potent, selective DOT1L inhibitor (Ki = 0.46 nM). Shows antiproliferative effects (EC50 values are 4.4, 8.1 and 10 μM for MV4-11, THP1 and NB4 leukemia cells, respectively). Binds to the DOT1L:nucleosome complex (Kd = 66 nM). Competes with SAM/SAH, but not the substrate nucleosome, on binding to DOT1L.
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精製度
> 98% -
CAS 番号
1381761-52-9 -
構造式
製品の特性
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体系名
5'-Deoxy-5'-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]adenosine hydrochloride -
分子量
577.13 -
分子式
C27H40N8O4.HCl -
保存方法
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 50 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
Cl.CC(C)(C)c1ccc(cc1)NC(=O)NCCCN(C[C@H]4O[C@@H](n3cnc2c(N)ncnc23)C(O)[C@H]4O)C(C)C -
由来
Synthetic
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (0)
ab145525 は論文での使用が確認できていません。