Dorsomorphin dihydrochloride, AMP-kinase inhibitor (ab144821)
Key features and details
- Potent, selective, reversible AMP-kinase inhibitor. BMP type I receptor inhibitor.
- CAS Number: 1219168-18-9
- Purity: > 99%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Dorsomorphin dihydrochloride, AMP-kinase inhibitor -
製品の詳細
Potent, selective, reversible AMP-kinase inhibitor. BMP type I receptor inhibitor. -
生理活性の詳細
Potent, selective, reversible AMP-kinase inhibitor (Ki = 109 nM). BMP type I receptor inhibitor. Induce autophagy in cancer cells independent of AMPK inhibition. Promotes cardiomyogenesis in embryonic stem cells. Reduces hepcidin, VCAM-1 and ICAM-1 expression in vivo.
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精製度
> 99% -
CAS 番号
1219168-18-9 -
構造式
製品の特性
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体系名
6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine dihydrochloride -
分子量
472.42 -
分子式
C24H25N5O.2HCl -
PubChem 登録番号
49761481 -
保存方法
Store at -20°C (desiccating conditions). -
溶解性
Soluble in water to 100 mM -
使用に関する注意
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3.Cl.Cl -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (4)
ab144821 は 4 報の論文で使用されています。
- Jo HY et al. Development of genetic quality tests for good manufacturing practice-compliant induced pluripotent stem cells and their derivatives. Sci Rep 10:3939 (2020). PubMed: 32127560
- Du L & Roberts JD Transforming growth factor-ß downregulates sGC subunit expression in pulmonary artery smooth muscle cells via MEK and ERK signaling. Am J Physiol Lung Cell Mol Physiol 316:L20-L34 (2019). PubMed: 30260287
- Hunt NJ et al. The effects of metformin on age-related changes in the liver sinusoidal endothelial cell. J Gerontol A Biol Sci Med Sci N/A:N/A (2019). PubMed: 31198956
- Zhang H et al. Transforming growth factor-ß stimulates Smad1/5 signaling in pulmonary artery smooth muscle cells and fibroblasts of the newborn mouse through ALK1. Am J Physiol Lung Cell Mol Physiol 313:L615-L627 (2017). PubMed: 28642261