SR95531 (Gabazine) (mM/ml), GABAA antagonist (ab144487)
Key features and details
- GABAA antagonist. 1 ml water soluble pack.
- CAS Number: 104104-50-9
- Purity: > 98%
- Soluble in 1 ml of water to give specified mM/ml concentration
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
SR95531 (Gabazine) (mM/ml), GABAA antagonist -
製品の詳細
GABAA antagonist. 1 ml water soluble pack. -
別名
- Gabazine
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生理活性の詳細
Selective, competitive GABAA receptor antagonist. Allosteric inhibitor of channel opening of the GABAA receptor. Displaces [3H]-GABA from rat brain membranes with a Ki of 150 nM.
Soluble in 1 ml water to give specified mM/ml concentration. Find out more. -
精製度
> 98% -
CAS 番号
104104-50-9 -
構造式
製品の特性
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体系名
2-(3-Carboxypropyl)-3-amino-6-(4 methoxyphenyl)pyridazinium bromide -
分子量
368.23 -
分子式
C15H17N3O3.HBr -
PubChem 登録番号
107895 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in 1 ml of water to give specified mM/ml concentration -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
[Br-].COc1ccc(cc1)C=2C=CC(=[NH2+])N(CCCC(=O)O)N=2 -
由来
Synthetic
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研究分野
画像
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2D chemical structure image of ab144487, SR95531 (Gabazine) (mM/ml), GABAA antagonist
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Increased tonic GABA currents and altered IPSC properties in TC neurons of SSADH−/− mice.
C, representative current traces from thalamocortical neurons of WT (left) and SSADH−/− (right) mice showing the difference in tonic current amplitude between the two genotypes. Dotted lines represent the initial baseline current prior to the focal application of 50 µM GBZ (white bar).
GBZ = Gabazine.
(From Figure 1 of Erringtom et al).
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (56)
ab144487 は 56 報の論文で使用されています。
- Chen CR et al. Dysfunctions of the paraventricular hypothalamic nucleus induce hypersomnia in mice. Elife 10:N/A (2021). PubMed: 34787078
- Shi HY et al. Lesion of intergeniculate leaflet GABAergic neurons attenuates sleep in mice exposed to light. Sleep 43:N/A (2020). PubMed: 31552427
- Kim YS et al. Characterizing the conductance underlying depolarization-induced slow current in cerebellar Purkinje cells. J Neurophysiol 109:1174-81 (2013). PubMed: 23197456
- Griguoli M et al. In hippocampal oriens interneurons anti-Hebbian long-term potentiation requires cholinergic signaling via a7 nicotinic acetylcholine receptors. J Neurosci 33:1044-9 (2013). PubMed: 23325242
- Borisovska M et al. Distinct modes of dopamine and GABA release in a dual transmitter neuron. J Neurosci 33:1790-6 (2013). PubMed: 23365218