Anti-CD24 抗体 [SN3] (ab134375)
Key features and details
- Mouse monoclonal [SN3] to CD24
- Suitable for: Flow Cyt
- Reacts with: Human
- Isotype: IgG1
Related conjugates and formulations
製品の概要
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製品名
Anti-CD24 antibody [SN3]
CD24 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [SN3] to CD24 -
由来種
Mouse -
アプリケーション
適用あり: Flow Cytmore details -
種交差性
交差種: Human -
免疫原
Full length native protein (purified) corresponding to Human CD24. Glycoproteins purified from Human NALM-1 cell line.
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ポジティブ・コントロール
- Flow Cyt: Human peripheral blood cells.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.40
Preservative: 0.1% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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精製度
Protein A purified -
特記事項(精製)
Purity: >95% (by SDS-PAGE). -
ポリ/モノ
モノクローナル -
クローン名
SN3 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Alternative Versions
- APC/Cy7® Anti-CD24 antibody [SN3], prediluted (ab197137)
- APC Anti-CD24 antibody [SN3] (ab239286)
- PerCP/Cy5.5® Anti-CD24 antibody [SN3] (ab239339)
- Alexa Fluor® 700 Anti-CD24 antibody [SN3] (ab269310)
- FITC Anti-CD24 antibody [SN3] (ab30350)
- PE Anti-CD24 antibody [SN3], prediluted (ab30351)
- PE Anti-CD24 antibody [SN3] (ab77219)
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Compatible Secondaries
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Conjugation kits
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab134375の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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Flow Cyt |
Use a concentration of 1 - 12 µg/ml.
ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
特記事項 |
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Flow Cyt
Use a concentration of 1 - 12 µg/ml. ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
ターゲット情報
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機能
Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. -
組織特異性
B-cells. Expressed in a number of B-cell lines including P32/SH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells. -
関連疾患
Genetic variations in CD24 are associated with susceptibility to multiple sclerosis (MS) [MIM:126200]. A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheat, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. Note=Polymorphisms in CD24 may act as a genetic modifier for susceptibility and progression of MS in some populations, perhaps by affecting the efficiency of CD24 expression on the cell surface. -
配列類似性
Belongs to the CD24 family. -
翻訳後修飾
Extensively O-glycosylated. -
細胞内局在
Cell membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 100133941 Human
- Omim: 600074 Human
- SwissProt: P25063 Human
- Unigene: 644105 Human
- Unigene: 721443 Human
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別名
- CD 24 antibody
- CD24 antibody
- CD24 antigen (small cell lung carcinoma cluster 4 antigen) antibody
see all
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プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (10)
ab134375 は 10 報の論文で使用されています。
- Yunusova N et al. Comparative Analysis of Tumor-Associated microRNAs and Tetraspanines from Exosomes of Plasma and Ascitic Fluids of Ovarian Cancer Patients. Int J Mol Sci 24:N/A (2022). PubMed: 36613908
- Yunusova NV et al. Exosomal Protease Cargo as Prognostic Biomarker in Colorectal Cancer. Asian Pac J Cancer Prev 22:861-869 (2021). PubMed: 33773551
- Yunusova N et al. Plasma Exosomes of Patients with Breast and Ovarian Tumors Contain an Inactive 20S Proteasome. Molecules 26:N/A (2021). PubMed: 34834058
- Nugent JL et al. A nonhuman primate model of vertical sleeve gastrectomy facilitates mechanistic and translational research in human obesity. iScience 24:103421 (2021). PubMed: 34877488
- Yunusova NV et al. Metalloproteinases at the surface of small extrcellular vesicles in advanced ovarian cancer: Relationships with ascites volume and peritoneal canceromatosis index. Clin Chim Acta 494:116-122 (2019). PubMed: 30904547
- Tugutova EA et al. Relation between Tetraspanin- Associated and Tetraspanin- Non- Associated Exosomal Proteases and Metabolic Syndrome in Colorectal Cancer Patients Asian Pac J Cancer Prev 20:809-815 (2019). PubMed: 30909692
- Aghajani Nargesi A et al. Renal Artery Stenosis Alters Gene Expression in Swine Scattered Tubular-Like Cells. Int J Mol Sci 20:N/A (2019). PubMed: 31614781
- Nargesi AA et al. Renovascular disease induces mitochondrial damage in swine scattered tubular cells. Am J Physiol Renal Physiol 317:F1142-F1153 (2019). PubMed: 31461348
- Pavel M et al. Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis. Nat Commun 9:2961 (2018). PubMed: 30054475
- Maliar A et al. Redirected T cells that target pancreatic adenocarcinoma antigens eliminate tumors and metastases in mice. Gastroenterology 143:1375-1384.e5 (2012). PubMed: 22819865