Picrotoxin, GABAA antagonist (ab120315)
Key features and details
- GABAA antagonist
- CAS Number: 124-87-8
- Soluble in DMSO to 100 mM and in ethanol to 50 mM (with heating)
- Form / State: Solid
- Source: Anamirta cocculus
製品の概要
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製品名
Picrotoxin, GABAA antagonist -
製品の詳細
GABAA antagonist -
生理活性の詳細
Plant alkaloid. Non-competitive GABAA antagonist. Also inhibits homomeric glycine receptor. Convulsant in vivo.
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特記事項
5g pack supplied as 5x1g
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CAS 番号
124-87-8 -
構造式
製品の特性
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体系名
1:1 mixture of picrotoxinin and picrotin -
分子量
602.59 -
分子式
C30H34O13 -
PubChem 登録番号
31304 -
保存方法
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 100 mM and in ethanol to 50 mM (with heating) -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CC(=C)[C@@H]1C2[C@@H]3[C@@]4([C@](C1C(=O)O2)(CC5[C@]4(O5)C(=O)O3)O)C.C[C@@]12[C@H]3C4[C@H](C([C@@]1(C[C@@H]5[C@]2(O5)C(=O)O3)O)C(=O)O4)C(C)(C)O -
由来
Anamirta cocculus
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (76)
ab120315 は 76 報の論文で使用されています。
- Oh H et al. Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice. Nat Commun 14:3547 (2023). PubMed: 37321992
- Morabito A et al. Activity-dependent modulation of NMDA receptors by endogenous zinc shapes dendritic function in cortical neurons. Cell Rep 38:110415 (2022). PubMed: 35196488
- Mishra P & Narayanan R Conjunctive changes in multiple ion channels mediate activity-dependent intrinsic plasticity in hippocampal granule cells. iScience 25:103922 (2022). PubMed: 35252816
- Martín-de-Saavedra MD et al. Shed CNTNAP2 ectodomain is detectable in CSF and regulates Ca2+ homeostasis and network synchrony via PMCA2/ATP2B2. Neuron 110:627-643.e9 (2022). PubMed: 34921780
- Bossi S et al. GluN3A excitatory glycine receptors control adult cortical and amygdalar circuits. Neuron 110:2438-2454.e8 (2022). PubMed: 35700736