Cell-permeable analog of arachidonic acid (ab120916). Widely used as an inhibitor of the 85-kDa cytosolic group IV phospholipase A2 (cPLA2) and calcium-independent group VI phospholipase A2 (iPLA2) (IC50 values are 1.5 and 6.0 μM, respectively) . In non-neural cells, also inhibits cyclooxygenase and acyltransferase activities.
Store at -20°C. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Store under desiccating conditions. The product can be stored for up to 12 months.
Farooqui AA et al. Inhibitors of brain phospholipase A2 activity: their neuropharmacological effects and therapeutic importance for the treatment of neurologic disorders. Pharmacol Rev58:591-620 (2006).
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Ackermann EJ et al. Inhibition of macrophage Ca(2+)-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones. J Biol Chem270:445-50 (1995).
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