製品の概要

  • 製品名A 769662
  • 製品の詳細
    AMP-activated protein kinase activator
  • 生理活性の詳細Potent, reversible activator of AMP-activated protein kinase (AMPK) (EC50 = 0.8 μM). Directly activates native rat AMPK by mimicking the effects of AMP - it activates AMPK both allosterically and by inhibiting dephosphorylation of AMPK. Shown to inhibit Na+-K+-ATPase at higher concentrations (IC50 = 57 μM) . Inhibits differentiation of adipocytes.
  • 精製度> 99%

法規制情報

製品の特性

  • 体系名6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile
  • 分子量360.39
  • 構造式Chemical Structure
  • 分子式C20H12N2O3S
  • CAS 番号844499-71-4
  • PubChem 登録番号54708532
  • 保存方法Store at +4°C. Store under Desiccating conditions. The product can be stored for up to 12 months.
  • 溶解性Soluble in DMSO to 100 mM and in ethanol to 25 mM
  • 使用に関する注意

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES 線形表記Oc1ccccc1c2ccc(cc2)c4csc3NC(=O)C(C#N)=C(O)c34
  • 由来

    Synthetic

  • 研究分野

    A 769662 (ab120335) 使用論文

    This product has been referenced in:
    • Benziane B  et al. AMP-activated protein kinase activator A-769662 is an inhibitor of the Na(+)-K(+)-ATPase. Am J Physiol Cell Physiol 297:C1554-66 (2009). Read more (PubMed: 19828836) »
    • Guigas B  et al. Beyond AICA riboside: in search of new specific AMP-activated protein kinase activators. IUBMB Life 61:18-26 (2009). Read more (PubMed: 18798311) »
    • Göransson O  et al. Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase. J Biol Chem 282:32549-60 (2007). Read more (PubMed: 17855357) »

    See all 4 Publications for this product

    Product Wall

    Thank you for contacting us.

    Ideally the reconstituted A769662 will be fully active for one month at -20C as given in the datasheet. I am sorry we have not done the stability test at -80C so we will not be able confirm it. There are however so...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"