ZM306416 hydrochloride, VEGFR1/2 tyrosine kinase activity inhibitor (ab144576)
Key features and details
- Potent and selective VEGFR1/2 tyrosine kinase activity inhibitor
- CAS Number: 196603-47-1
- Purity: > 98%
Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
ZM306416 hydrochloride, VEGFR1/2 tyrosine kinase activity inhibitor -
製品の詳細
Potent and selective VEGFR1/2 tyrosine kinase activity inhibitor -
生理活性の詳細
Potent and selective VEGFR1/2 inhibitor (IC50 values are 100 nM and 2 μM for KDR and Flt respectively). Shows antiproliferative effects in vivo. Orally active. -
精製度
> 98% -
CAS 番号
196603-47-1 -
構造式
製品の特性
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体系名
4-[(4'-Chloro-2'-fluoro)phenylamino]-6,7-dimethoxyquinazoline hydrochloride
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分子量
370.12 -
分子式
C16H13ClFN3O2.HCl -
PubChem 登録番号
5329006 -
保存方法
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 10 mM
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使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
COC1=C(C=C2C(=C1)C(=NC=N2)NC3=C(C=C(C=C3)Cl)F)OC -
由来
Synthetic
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研究分野
画像
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (1)
ab144576 は 1 報の論文で使用されています。
- Baba T et al. Role of IL-4 in bone marrow driven dysregulated angiogenesis and age-related macular degeneration. Elife 9:N/A (2020). PubMed: 32366355