Anti-WBSCR22 抗体 (ab97911)
Key features and details
- Rabbit polyclonal to WBSCR22
- Suitable for: IHC-P, WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-WBSCR22 antibody -
製品の詳細
Rabbit polyclonal to WBSCR22 -
由来種
Rabbit -
アプリケーション
適用あり: IHC-P, WBmore details -
種交差性
交差種: Human -
免疫原
Recombinant fragment, corresponding to a sequence within amino acids 1-233 of Human WBSCR22 (NP_059998).
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine) -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab97911の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-P |
1/100 - 1/250. The staining pattern is dependent on the antibody titer and nature of the biology. Proliferating tumor cells might be positive for nuclear staining while the differentiated cells show no nuclear staining. Antibody titer and antigen retrieval time should be adjusted.
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WB |
1/500 - 1/3000. Predicted molecular weight: 32 kDa.
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特記事項 |
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IHC-P
1/100 - 1/250. The staining pattern is dependent on the antibody titer and nature of the biology. Proliferating tumor cells might be positive for nuclear staining while the differentiated cells show no nuclear staining. Antibody titer and antigen retrieval time should be adjusted. |
WB
1/500 - 1/3000. Predicted molecular weight: 32 kDa. |
ターゲット情報
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機能
Methyltransferase that may act on DNA. -
組織特異性
Strongly expressed in heart, skeletal muscle and kidney. Also expressed in spleen, liver, lung and testis. -
関連疾患
Note=WBSCR22 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of WBSCR22 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. -
配列類似性
Belongs to the methyltransferase superfamily. -
細胞内局在
Nucleus. - Information by UniProt
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参照データベース
- Entrez Gene: 114049 Human
- SwissProt: O43709 Human
- Unigene: 647063 Human
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別名
- HASJ4442 antibody
- HUSSY 3 antibody
- HUSSY3 antibody
see all
画像
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (3)
ab97911 は 3 報の論文で使用されています。
- Garcia BCB et al. BUD23-TRMT112 interacts with the L protein of Borna disease virus and mediates the chromosomal tethering of viral ribonucleoproteins. Microbiol Immunol 65:492-504 (2021). PubMed: 34324219
- Zorbas C et al. The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis. Mol Biol Cell 26:2080-95 (2015). WB . PubMed: 25851604
- Ounap K et al. The Human WBSCR22 Protein Is Involved in the Biogenesis of the 40S Ribosomal Subunits in Mammalian Cells. PLoS One 8:e75686 (2013). ICC/IF ; Human . PubMed: 24086612