Anti-VEGF Receptor 3 抗体 [RM0003-5F63] (ab51874)
Key features and details
- Rat monoclonal [RM0003-5F63] to VEGF Receptor 3
- Suitable for: IHC-P
- Reacts with: Mouse
- Isotype: IgG2
製品の概要
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製品名
Anti-VEGF Receptor 3 antibody [RM0003-5F63]
VEGF Receptor 3 一次抗体 製品一覧 -
製品の詳細
Rat monoclonal [RM0003-5F63] to VEGF Receptor 3 -
由来種
Rat -
特異性
No cross reactivity to mouse VEGFR1 and VEGFR2. -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Mouse -
免疫原
Recombinant full length protein corresponding to Mouse VEGF Receptor 3 (extracellular).
Database link: P35917 -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
Constituent: PBS -
Concentration information loading...
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精製度
Protein G purified -
ポリ/モノ
モノクローナル -
クローン名
RM0003-5F63 -
アイソタイプ
IgG2 -
研究分野
関連製品
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Compatible Secondaries
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab51874の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
IHC-P |
Use at an assay dependent concentration.
Use at 1/100-1/500 dilution |
特記事項 |
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IHC-P
Use at an assay dependent concentration. Use at 1/100-1/500 dilution |
ターゲット情報
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機能
Receptor for VEGFC. Has a tyrosine-protein kinase activity. -
組織特異性
Placenta, lung, heart, and kidney, does not seem to be expressed in pancreas and brain. -
関連疾患
Defects in FLT4 are the cause of lymphedema hereditary type 1A (LMPH1A) [MIM:153100]; also known as Nonne-Milroy lymphedema or Milroy disease. Hereditary lymphedema is a chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections and physical impairment.
Note=Defects in FLT4 are found in juvenile hemangioma. Juvenile hemangiomas are the most common tumors of infancy, occurring as many as 10% of all births. These benign vascular lesions enlarge rapidly during the first year of life by hyperplasia of endothelial cells and attendant pericytes, and then spontaneously involute over a period of years, leaving loose fibrofatty tissue. -
配列類似性
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 14257 Mouse
- SwissProt: P35917 Mouse
- Unigene: 3291 Mouse
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別名
- EC 2.7.10.1 antibody
- flt 4 antibody
- FLT-4 antibody
see all
画像
データシートおよび資料
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Datasheet download
参考文献 (4)
ab51874 は 4 報の論文で使用されています。
- Follain G et al. Impairing flow-mediated endothelial remodeling reduces extravasation of tumor cells. Sci Rep 11:13144 (2021). PubMed: 34162963
- Henri O et al. Selective Stimulation of Cardiac Lymphangiogenesis Reduces Myocardial Edema and Fibrosis Leading to Improved Cardiac Function Following Myocardial Infarction. Circulation 133:1484-97; discussion 1497 (2016). PubMed: 26933083
- Sun Z et al. Downregulation of long non-coding RNA ANRIL suppresses lymphangiogenesis and lymphatic metastasis in colorectal cancer. Oncotarget 7:47536-47555 (2016). PubMed: 27286457
- Park JA et al. Endothelial Snail Regulates Capillary Branching Morphogenesis via Vascular Endothelial Growth Factor Receptor 3 Expression. PLoS Genet 11:e1005324 (2015). PubMed: 26147525