Anti-USP2 抗体 (ab101609)
Key features and details
- Rabbit polyclonal to USP2
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-USP2 antibody
USP2 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to USP2 -
由来種
Rabbit -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse -
免疫原
Synthetic peptide raised against c-terminal domain of Human USP2, conjugated to KLH.
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ポジティブ・コントロール
- Human placenta, Human testis
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.4
Preservative: 0.1% Sodium azide
Constituent: PBS -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab101609の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-P |
Use a concentration of 5 µg/ml. Requires pretreatment with proteinase K.
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特記事項 |
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IHC-P
Use a concentration of 5 µg/ml. Requires pretreatment with proteinase K. |
ターゲット情報
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機能
Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. -
組織特異性
Expressed in mesangial cells of the kidney and in different types of glomerulonephritides (at protein level). -
配列類似性
Belongs to the peptidase C19 family. USP2 subfamily. -
ドメイン
The different N-terminus extensions of isoform 1 and isoform 4 determine their respective subcellular localization and differentiel effect on myoblast fusion and accumulation of muscle-specific proteins. The different N-terminus extensions of isoform 1 and isoform 4 are not essential for their catalytic activity. -
細胞内局在
Nucleus and Cytoplasm. Cytoplasm > perinuclear region. Localizes in the spermatid head in late-elongating spermatids in the thin area between the outer acrosomal membrane and the plasma membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 9099 Human
- Entrez Gene: 53376 Mouse
- Omim: 604725 Human
- SwissProt: O75604 Human
- SwissProt: O88623 Mouse
- Unigene: 524085 Human
- Unigene: 272770 Mouse
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別名
- 41 kDa ubiquitin specific protease antibody
- 41 kDa ubiquitin-specific protease antibody
- Deubiquitinating enzyme 2 antibody
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画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (1)
ab101609 は 1 報の論文で使用されています。
- Wei T et al. Ubiquitin-specific protease 2 decreases p53-dependent apoptosis in cutaneous T-cell lymphoma. Oncotarget 7:48391-48400 (2016). PubMed: 27351221