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Product name
Anti-TrkC antibody
TrkC 抗体 (14件) 一覧
Description
Rabbit polyclonal to TrkC
Specificity
ab75174 appears to be specific for extracellular domain of rat, mouse, human and monkey TrkC
Tested applications
WB, IHC-P, IHC-Fr, ICC/IFmore details
Cross reactivity
Reacts with
Mouse, Rat, Human, Monkey
Immunogen
A synthetic peptide from the extracellular domain of rat, mouse, human, monkey TrkC conjugated to an immunogenic carrier protein
Positive control
Rat DRG
Properties
Form
Lyophilised:
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C (add glycerol to a final volume of 40% for extra stability). Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: Whole serum
Concentration
Concentration information loading...
Purity
Whole antiserum
Clonality
Polyclonal
Isotype
IgG
Applications
Show applications key
Our Abpromise guarantee covers the use of ab75174 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/300 - 1/4000. Predicted molecular weight: 94 kDa.This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.
IHC-P
IHC-P: 1/300 - 1/4000.IHC-P: 1/300 - 1/4000.
IHC-Fr: 1/300 - 1/4000.
ICC/IF: 1/500.
Target
Function
Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.
Tissue specificity
Widely expressed but mainly in nervous tissue. Isoform B is expressed at higher levels in adult brain than in fetal brain.
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 2 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain.
Contains 1 protein kinase domain.
Post-translational
modifications
Ligand-mediated auto-phosphorylation.
Cellular localization
Membrane.
Target information above from: UniProt accessionQ16288
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- EC 2.7.10.1 antibody
- ETS related protein neurotrophic receptor tyrosine kinase fusion antibody
- ETV6 NTRK3 fusion antibody
see all
Database links
- Entrez Gene: 4916 Human
- Entrez Gene: 18213 Mouse
- Entrez Gene: 29613 Rat
- Omim: 191316 Human
- SwissProt: Q16288 Human
- SwissProt: Q6VNS1 Mouse
- SwissProt: Q03351 Rat
- Unigene: 410969 Human
see all
Anti-TrkC antibody images:
Immunocytochemistry/ Immunofluorescence - TrkC antibody (ab75174)
ab75174 at 1/500 dilution staining of rat DRG using Immunofluorescence
Immunocytochemistry/ Immunofluorescence - TrkC antibody (ab75174)
ab75174 at 1/500 dilution stained rat DRG, DAPI counterstained, using Immunofluorescence
References for Anti-TrkC antibody (ab75174)
ab75174 has not yet been referenced specifically in any publications.
Publishing research using ab75174? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"