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Anti-TrkB (phospho Y816) antibody (ab75173)

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Overview

Product name

Anti-TrkB (phospho Y816) antibody
TrkB 抗体 (22件) 一覧

Description

Rabbit polyclonal to TrkB (phospho Y816)

Tested applications

WB, IHC-P, IHC-Frmore details

Cross reactivity

Reacts with

Mouse, Rat, Human, Prairie Vole

Immunogen

A synthetic peptide from the region around (and including) phospho Y816 site of rat TrkB conjugated to an immunogenic carrier protein. The antigen is homologous in rat and mouse.

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C (add glycerol to a final volume of 40% for extra stability). Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: Whole serum

Purity

Whole antiserum

Clonality

Polyclonal

Isotype

IgG

Research areas

Cancer >> Oncoproteins/suppressors >> Oncoproteins >> Growth factor receptors
Neuroscience >> Neurology process >> Growth and Development >> Neurotrophins

Applications

Show applications key

Our Abpromise guarantee covers the use of ab75173 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application notes

IHC-P: 1/300 - 1/2000. Antigen retrieval is recommended.
IHC-Fr: 1/300 - 1/2000.
WB: 1/300 - 1/2000. Predicted molecular weight: 92 kDa.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Function

Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.

Tissue specificity

Isoform TrkB is widely expressed, mainly in the nervous tissue. In the CNS, expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular layer of the cerebellum, brain stem, and spinal cord. In the peripheral nervous system, it is expressed in many cranial ganglia, the ophtalmic nerve, the vestibular system, multiple facial structures, the submaxillary glands, and dorsal root ganglia. Isoform TrkB-T1 is expressed in multiple tissues, mainly in brain, pancreas, kidney and heart. Isoform TrkB-T-Shc is predominantly expressed in brain.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 2 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain.
Contains 1 protein kinase domain.

Post-translational
modifications

Ligand-mediated auto-phosphorylation.

Cellular localization

Membrane.

Target information above from: UniProt accessionQ16620 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • AI848316 antibody
  • BDNF tropomyosine receptor kinase B antibody
  • BDNF/NT 3 growth factors receptor antibody
  • BDNF/NT-3 growth factors receptor antibody
  • Brain derived neurotrophic factor receptor antibody
  • C030027L06Rik antibody
  • EC 2.7.10.1 antibody
  • GP145 TrkB antibody
  • GP145-TrkB antibody
  • GP145-TrkB/GP95-TrkB antibody
  • GP95 TrkB antibody
  • Neurotrophic tyrosine kinase receptor type 2 antibody
  • Neurotrophin receptor tyrosine kinase type 2 antibody
  • NTRK 2 antibody
  • Ntrk2 antibody
  • NTRK2_HUMAN antibody
  • Obesity, hyperphagia, and developmental delay, included antibody
  • RATTRKB1 antibody
  • Tkrb antibody
  • Trk B antibody
  • Trk-B antibody
  • TRKB antibody
  • TrkB tyrosine kinase antibody
  • TRKB1 antibody
  • tyrosine kinase receptor B antibody
  • Tyrosine receptor kinase B antibody
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Database links

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References for Anti-TrkB (phospho Y816) antibody (ab75173)

This product has been referenced in:

  • Stansfield KH  et al. Dysregulation of BDNF-TrkB signaling in developing hippocampal neurons by Pb2+: Implications for an environmental basis of neurodevelopmental disorders. Toxicol Sci : (2012).Read more (PubMed: 22345308) »

See 1 publication for this product

Publishing research using ab75173? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"