Anti-Synapsin I 抗体 (ab8)
Key features and details
- Rabbit polyclonal to Synapsin I
- Suitable for: WB
- Reacts with: Rat
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-Synapsin I antibody
Synapsin I 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Synapsin I -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Rat -
免疫原
Full length native protein (purified) corresponding to Cow Synapsin I.
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ポジティブ・コントロール
- WB: Rat brain tissue lysates
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.50
Constituents: 0.24% HEPES, 0.87% Sodium chloride, 0.0001% BSA, 50% Glycerol -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab8の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/1000. Predicted molecular weight: 80 kDa.
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特記事項 |
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WB
1/1000. Predicted molecular weight: 80 kDa. |
ターゲット情報
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機能
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level. -
関連疾患
Defects in SYN1 are a cause of epilepsy X-linked with variable learning disabilities and behavior disorders [MIM:300491]. XELBD is characterized by variable combinations of epilepsy, learning difficulties, macrocephaly, and aggressive behavior. -
配列類似性
Belongs to the synapsin family. -
翻訳後修飾
Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal. Phosphorylated upon DNA damage, probably by ATM or ATR. -
細胞内局在
Cell junction > synapse. Golgi apparatus. - Information by UniProt
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参照データベース
- Entrez Gene: 24949 Rat
- SwissProt: P09951 Rat
- Unigene: 9923 Rat
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別名
- Brain protein 4.1 antibody
- SYN 1 antibody
- SYN 1a antibody
see all
画像
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Anti-Synapsin I antibody (ab8) + Rat brain tissue lysate at 10 µg
Predicted band size: 80 kDa
Observed band size: 78 kDa why is the actual band size different from the predicted?
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (52)
ab8 は 52 報の論文で使用されています。
- Li SS et al. Electroacupuncture treatment improves motor function and neurological outcomes after cerebral ischemia/reperfusion injury. Neural Regen Res 17:1545-1555 (2022). PubMed: 34916440
- Gaikwad S et al. Tau oligomer induced HMGB1 release contributes to cellular senescence and neuropathology linked to Alzheimer's disease and frontotemporal dementia. Cell Rep 36:109419 (2021). PubMed: 34289368
- Fu ZW et al. The metabolite methylglyoxal-mediated gene expression is associated with histone methylglyoxalation. Nucleic Acids Res 49:1886-1899 (2021). PubMed: 33476385
- Sadek J et al. Pharmacological or genetic inhibition of iNOS prevents cachexia-mediated muscle wasting and its associated metabolism defects. EMBO Mol Med 13:e13591 (2021). PubMed: 34096686
- Held RG et al. Synapse and Active Zone Assembly in the Absence of Presynaptic Ca2+ Channels and Ca2+ Entry. Neuron 107:667-683.e9 (2020). PubMed: 32616470