Anti-Sialoadhesin/CD169 抗体 [3D6.112] (ab53443)
Key features and details
- Rat monoclonal [3D6.112] to Sialoadhesin/CD169
- Suitable for: IHC-Fr
- Reacts with: Mouse
- Isotype: IgG2a
製品の概要
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製品名
Anti-Sialoadhesin/CD169 antibody [3D6.112]
Sialoadhesin/CD169 一次抗体 製品一覧 -
製品の詳細
Rat monoclonal [3D6.112] to Sialoadhesin/CD169 -
由来種
Rat -
アプリケーション
適用あり: IHC-Frmore details -
種交差性
交差種: Mouse -
免疫原
Full length native protein (purified). This information is proprietary to Abcam and/or its suppliers.
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特記事項
Fusion partners: Spleen cells from an immunised AO rat were fused with the cells of the Y3 rat myeloma cell line.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
バッファー
Preservative: 0.09% Sodium azide
Constituent: PBS -
Concentration information loading...
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精製度
Protein G purified -
特記事項(精製)
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant. -
一次抗体 備考
Fusion partners: Spleen cells from an immunised AO rat were fused with the cells of the Y3 rat myeloma cell line. -
ポリ/モノ
モノクローナル -
クローン名
3D6.112 -
アイソタイプ
IgG2a -
研究分野
関連製品
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Compatible Secondaries
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Conjugation kits
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab53443の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
IHC-Fr |
1/50 - 1/100.
|
特記事項 |
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IHC-Fr
1/50 - 1/100. |
ターゲット情報
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機能
Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis. -
組織特異性
Expressed by macrophages in various tissues. High levels are found in spleen, lymph node, perivascular macrophages in brain and lower levels in bone marrow, liver Kupffer cells and lamina propria of colon and lung. Also expressed by inflammatory macrophages in rheumatoid arthritis. -
配列類似性
Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Contains 16 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
細胞内局在
Secreted and Cell membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 20612 Mouse
- SwissProt: Q62230 Mouse
- Unigene: 1374 Mouse
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別名
- CD169 antibody
- CD169 antigen antibody
- dJ1009E24.1 antibody
see all
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (6)
ab53443 は 6 報の論文で使用されています。
- Chen Q et al. Resident macrophages restrain pathological adipose tissue remodeling and protect vascular integrity in obese mice. EMBO Rep 22:e52835 (2021). PubMed: 34196465
- Zheng J et al. Evaluation of metastatic niches in distant organs after surgical removal of tumor-bearing lymph nodes. BMC Cancer 18:608 (2018). PubMed: 29848296
- Ibrahim MK et al. Deficiency of lymph node-resident dendritic cells (DCs) and dysregulation of DC chemoattractants in a malnourished mouse model of Leishmania donovani infection. Infect Immun 82:3098-112 (2014). PubMed: 24818662
- Ibrahim MK et al. The malnutrition-related increase in early visceralization of Leishmania donovani is associated with a reduced number of lymph node phagocytes and altered conduit system flow. PLoS Negl Trop Dis 7:e2329 (2013). Mouse . PubMed: 23967356
- Xiong YS et al. Contribution of monocytes Siglec-1 in stimulating T cells proliferation and activation in atherosclerosis. Atherosclerosis 224:58-65 (2012). PubMed: 22789514
- Zollo M et al. Targeting monocyte chemotactic protein-1 synthesis with bindarit induces tumor regression in prostate and breast cancer animal models. Clin Exp Metastasis 29:585-601 (2012). PubMed: 22484917