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Anti-Serotonin antibody (ab66047)

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Overview

Product name

Anti-Serotonin antibody
Serotonin 抗体 (10件) 一覧

Description

Goat polyclonal to Serotonin

Tested applications

IHC-Fr, IHC-FoFrmore details

Immunogen

Serotonin whole molecule conjugated to BSA with paraformaldehyde.

Positive control

Rat hypothalamus, raphe nuclei and spinal cord.

General notes

Upon delivery dilute with phosphate buffer or Tris buffer at dilutions no higher than 1/10, aliquot and freeze at -15° C or lower. Antibody can be stored for up to six months if handled as described above.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: Whole serum

Purity

Whole antiserum

Clonality

Polyclonal

Isotype

IgG

Research areas

Neuroscience >> Neurotransmitter >> Biogenic Amines >> Serotonin / 5HT

  • Immunohistochemistry (PFA perfusion fixed frozen sections) - Serotonin antibody (ab66047)Immunohistochemistry (PFA perfusion fixed frozen sections) - Serotonin antibody (ab66047) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab66047 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Relevance

Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine neurotransmitter synthesised in serotonergic neurons in the central nervous system and enterochromaffin cells in the gastrointestinal tract. Serotonin plays an important part in the biochemistry of depression, migraine, bipolar disorder and anxiety. It is also believed to be influential on sexuality and appetite. 5-HT is generally thought not to be released from synaptic terminal buttons in the manner of classical neurotransmission but from serotonergic varacosities into the extra neuronal space. From here it is free to diffuse over a relatively large region of space (>20µm) and activate 5-HT receptors located on the dendrites, cell bodies and presynaptic terminals of adjacent neurons. Serotonergic action is terminated primarily via uptake of 5-HT from the synapse. This is through the specific monoamine transporter for 5-HT, 5-HT reuptake transporter, on the presynaptic neuron. The pharmacology of 5-HT is extremely complex, with its actions being mediated by a large and diverse range of 5-HT receptors.

Cellular localization

Cytoplasmic and Secreted

Alternative names

  • 5 HT 5A antibody
  • 5 HT antibody
  • 5 HT5A antibody
  • 5 hydroxytryptamine antibody
  • 5HT antibody
see all

Anti-Serotonin antibody images:

  Immunohistochemistry (PFA perfusion fixed frozen sections) - Serotonin antibody (ab66047)

Immunohistochemistry (PFA perfusion fixed frozen sections) - Serotonin antibody (ab66047)

ab66407 staining of rat hypothalamus using 4+ biotin-streptavidin/HRP staing at 1/4000.

References for Anti-Serotonin antibody (ab66047)

This product has been referenced in:

  • Vann SD Gudden's ventral tegmental nucleus is vital for memory: re-evaluating diencephalic inputs for amnesia. Brain 132:2372-84 (2009).Read more (PubMed: 19602577) »

See 1 publication for this product

Publishing research using ab66047? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"