Anti-SUN2 抗体 (ab87036)
Key features and details
- Rabbit polyclonal to SUN2
- Suitable for: ICC
- Reacts with: Mouse
- Isotype: IgG
製品の概要
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製品名
Anti-SUN2 antibody
SUN2 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to SUN2 -
由来種
Rabbit -
アプリケーション
適用あり: ICCmore details -
種交差性
交差種: Mouse -
免疫原
Synthetic peptide:
MSRRSQRLTRYSQDDNDG
, corresponding to N terminal amino acids 1-18 of Mouse SUN2 -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
バッファー
Preservative: 0.1% Sodium azide
Constituent: Whole serum -
Concentration information loading...
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精製度
Whole antiserum -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab87036の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
ICC |
1/500.
|
特記事項 |
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ICC
1/500. |
ターゲット情報
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関連性
SUN proteins form part of the LINC complex - a protein bridge that spans the nuclear envelope linking the nucleoskeleten to the actin cytoskeleten. They are located on the inner nuclear membrane side of the complex. The LINC complex is thought to function in controlling nuclear position, contributing to mechanical resistance and the overall architecture of the cell. SUN2 can exist in a heterodimer with SUN1. Both can interact with lamins and nesprins in the nuclear envelope. -
細胞内局在
Nuclear membrane, endosome membrane, mitotic spindle organization. -
参照データベース
- Entrez Gene: 223697 Mouse
- SwissProt: Q8BJS4 Mouse
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別名
- FRIGG antibody
- KIAA0668 antibody
- nuclear envelope protein antibody
see all
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (8)
ab87036 は 8 報の論文で使用されています。
- Byron A et al. Characterisation of a nucleo-adhesome. Nat Commun 13:3053 (2022). PubMed: 35650196
- Östlund C et al. Hepatocytes Deficient in Nuclear Envelope Protein Lamina-associated Polypeptide 1 are an Ideal Mammalian System to Study Intranuclear Lipid Droplets. J Lipid Res 63:100277 (2022). PubMed: 36100089
- Antoku S et al. ERK1/2 Phosphorylation of FHOD Connects Signaling and Nuclear Positioning Alternations in Cardiac Laminopathy. Dev Cell 51:602-616.e12 (2019). PubMed: 31794718
- Saunders CA et al. TorsinA controls TAN line assembly and the retrograde flow of dorsal perinuclear actin cables during rearward nuclear movement. J Cell Biol 216:657-674 (2017). PubMed: 28242745
- Yang Z et al. Nuclear Envelope Rupture Is Enhanced by Loss of p53 or Rb. Mol Cancer Res 15:1579-1586 (2017). PubMed: 28811362
- Zhu R et al. Centrifugal Displacement of Nuclei Reveals Multiple LINC Complex Mechanisms for Homeostatic Nuclear Positioning. Curr Biol 27:3097-3110.e5 (2017). PubMed: 28988861
- Gutiérrez-Fernández A et al. Loss of MT1-MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid. EMBO J 34:1875-88 (2015). PubMed: 25991604
- Guo Y & Zheng Y Lamins position the nuclear pores and centrosomes by modulating dynein. Mol Biol Cell 26:3379-89 (2015). ICC/IF . PubMed: 26246603