SR95531 (Gabazine), GABAA antagonist (ab120042)
Key features and details
- GABAA antagonist
- CAS Number: 104104-50-9
- Soluble in water to 25 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
SR95531 (Gabazine), GABAA antagonist -
製品の詳細
GABAA antagonist -
別名
- Gabazine
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生理活性の詳細
Selective, competitive GABAA receptor antagonist. Allosteric inhibitor of channel opening of the GABAA receptor. Displaces [3H]-GABA from rat brain membranes with a Ki of 150 nM.
Also available in simple stock solutions (ab144487) - add 1 ml of water to get an exact, ready-to-use concentration. -
CAS 番号
104104-50-9 -
構造式
製品の特性
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体系名
2-(3-Carboxypropyl)-3-amino-6-(4 methoxyphenyl)pyridazinium bromide -
分子量
368.23 -
分子式
C15H17N3O3.HBr -
PubChem 登録番号
107895 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 25 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
[Br-].COc1ccc(cc1)C=2C=CC(=[NH2+])N(CCCC(=O)O)N=2 -
由来
Synthetic
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研究分野
画像
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2D chemical structure image of ab120042, SR95531 (Gabazine), GABAA antagonist
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Expression of DISC1ΔC is induced by postnatal administration of 4-OHT as seen by expression of GFP fused to DISC1ΔC in this P28 brain slice. No GFP expression is observed in vehicle treated animals (- 4-OHT). Scale bar equals 100 µm. Performed in the presence of gabazine (5 µM) and TTX (1 µM).
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A. Purkinje cell response to simulated ischemia (OGD only) in the continuous presence of the GABAA antagonist GABAzine (ab120042, 10 μM), and during subsequent block of glutamate receptors with AP5 (ab120003, 50 μM) + NBQX (ab120045, 25 μM). B. Bar charts summarize the timing and magnitude of ischemia-induced glutamate currents (for both methods of simulating ischemia) with and without GABAA receptors blocked. Iglu is the magnitude of current blocked by AP5 (ab120003, 50 μM) + NBQX (ab120045, 25 μM).
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (152)
ab120042 は 152 報の論文で使用されています。
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- Beeson KA et al. α2δ-2 is required for depolarization-induced suppression of excitation in Purkinje cells. J Physiol 600:111-122 (2022). PubMed: 34783012
- Zarhin D et al. Disrupted neural correlates of anesthesia and sleep reveal early circuit dysfunctions in Alzheimer models. Cell Rep 38:110268 (2022). PubMed: 35045289