Anti-SP110 抗体 (ab67220)
Key features and details
- Rabbit polyclonal to SP110
- Suitable for: ICC/IF, WB, IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-SP110 antibody
SP110 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to SP110 -
由来種
Rabbit -
特異性
This product recognizes isoforms b and c. -
アプリケーション
適用あり: ICC/IF, WB, IHC-Pmore details -
種交差性
交差種: Human -
免疫原
A 15 amino acid synthetic peptide derived from near the carboxy terminus of human SP110; (NP_004501.3, SP110 isoform b).
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ポジティブ・コントロール
- Human brain tissue. HeLa cell lysate.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. -
バッファー
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab67220の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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ICC/IF | ||
WB | ||
IHC-P |
特記事項 |
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WB: Use at a concentration of 1 - 2 µg/ml. Detects a band of approximately 63 kDa (predicted molecular weight of isoform b 63kDa, for longest isoform: 79 kDa).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
ターゲット情報
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機能
Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE). -
組織特異性
Highly expressed in peripheral blood leukocytes and spleen. Detected at intermediate levels in thymus, prostate, testis, ovary, small intestine and colon, and at low levels in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. -
関連疾患
Defects in SP110 are the cause of hepatic venoocclusive disease with immunodeficiency (VODI) [MIM:235550]. VODI is an autosomal recessive primary immunodeficiency associated with hepatic vascular occlusion and fibrosis. The immunodeficiency is characterized by severe hypogammaglobulinemia, combined T and B cell immunodeficiency, absent lymph node germinal centers, and absent tissue plasma cells. -
配列類似性
Contains 1 bromo domain.
Contains 1 HSR domain.
Contains 1 PHD-type zinc finger.
Contains 1 SAND domain. -
翻訳後修飾
Phosphorylated (isoform 2). -
細胞内局在
Nucleus. Found in the nuclear body. - Information by UniProt
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参照データベース
- Entrez Gene: 3431 Human
- Omim: 604457 Human
- SwissProt: Q9HB58 Human
- Unigene: 145150 Human
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別名
- FLJ22835 antibody
- IFI 41 antibody
- IFI 75 antibody
see all
画像
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Lane 1 : Anti-SP110 antibody (ab67220) at 0.5 µg/ml
Lane 2 : Anti-SP110 antibody (ab67220) at 1 µg/ml
Lane 3 : Anti-SP110 antibody (ab67220) at 2 µg/ml
All lanes : HeLa cell lysate
Lysates/proteins at 15 µg per lane.
Predicted band size: 63 kDa
Observed band size: 63 kDa -
ab67220 at 2.5µg/ml staining of SP110 in human brain tissue using IHC-P.
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Immunofluorescence of IPR1 in Human Brain cells using ab67220 at 50 ug/ml.
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab67220 は論文での使用が確認できていません。