Anti-SOAT 1/ACAT1 抗体 (ab39327)
Key features and details
- Rabbit polyclonal to SOAT 1/ACAT1
- Suitable for: WB, IHC-P
- Reacts with: Rat, Human
- Isotype: IgG
製品の概要
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製品名
Anti-SOAT 1/ACAT1 antibody
SOAT 1/ACAT1 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to SOAT 1/ACAT1 -
由来種
Rabbit -
アプリケーション
適用あり: WB, IHC-Pmore details -
種交差性
交差種: Rat, Human
交差が予測される動物種: Cynomolgus monkey -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol, 0.1% BSA -
Concentration information loading...
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精製度
Affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab39327の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
Use at an assay dependent concentration. Predicted molecular weight: 47 kDa.
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IHC-P |
Use at an assay dependent concentration.
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特記事項 |
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WB
Use at an assay dependent concentration. Predicted molecular weight: 47 kDa. |
IHC-P
Use at an assay dependent concentration. |
ターゲット情報
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機能
Catalyzes the formation of fatty acid-cholesterol esters. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. -
配列類似性
Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily. -
細胞内局在
Endoplasmic reticulum membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 6646 Human
- Entrez Gene: 81782 Rat
- Omim: 102642 Human
- SwissProt: P35610 Human
- SwissProt: O70536 Rat
- Unigene: 496383 Human
- Unigene: 59 Rat
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別名
- ACACT antibody
- ACAT antibody
- ACAT-1 antibody
see all
画像
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All lanes : Anti-SOAT 1/ACAT1 antibody (ab39327)
Lane 1 : Rat Liver (30µg)
Lane 2 : HepG2 cell lysate (30µg)
Predicted band size: 47 kDa
Observed band size: 50,65 kDa why is the actual band size different from the predicted?
The 65 kDa band detected is the native form of ACAT1. -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of human adreanal tissue using ab39327 at 1/200 after heat induced antigen reteval in pH 6.0 citrate buffer. DAB staining.
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (15)
ab39327 は 15 報の論文で使用されています。
- Eckhardt C et al. High expression of Sterol-O-Acyl transferase 1 (SOAT1), an enzyme involved in cholesterol metabolism, is associated with earlier biochemical recurrence in high risk prostate cancer. Prostate Cancer Prostatic Dis 25:484-490 (2022). PubMed: 34326474
- Zhong N et al. piRNA-6426 increases DNMT3B-mediated SOAT1 methylation and improves heart failure. Aging (Albany NY) 14:2678-2694 (2022). PubMed: 35354120
- Ayyagari V et al. Assessment of the diagnostic and prognostic relevance of ACAT1 and CE levels in plasma, peritoneal fluid and tumor tissue of epithelial ovarian cancer patients - a pilot study. BMC Cancer 22:387 (2022). PubMed: 35399074
- Löhr M et al. SOAT1: A Suitable Target for Therapy in High-Grade Astrocytic Glioma? Int J Mol Sci 23:N/A (2022). PubMed: 35409086
- Zhu T et al. SOAT1 Promotes Gastric Cancer Lymph Node Metastasis Through Lipid Synthesis. Front Pharmacol 12:769647 (2021). PubMed: 34790132