SB 216763, GSK3 inhibitor (ab120202)
Key features and details
- Potent selective GSK3 inhibitor
- CAS Number: 280744-09-4
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
SB 216763, GSK3 inhibitor -
製品の詳細
Potent selective GSK3 inhibitor -
生理活性の詳細
Potent and selective GSK3 inhibitor (Ki= 9 nM for GSK-3α). Has little activity against 24 other protein kinases (IC50 > 10 μM). Stimulates glycogen synthesis, gene transcription and is cardio- and neuroprotective.
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CAS 番号
280744-09-4 -
構造式
製品の特性
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体系名
3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione -
分子量
371.22 -
分子式
C19H12Cl2N2O2 -
PubChem 登録番号
176158 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
Clc1ccc(c(Cl)c1)C=4C(=O)NC(=O)C=4c3cn(C)c2ccccc23 -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (7)
ab120202 は 7 報の論文で使用されています。
- Cao S et al. Effects of cGMP/Akt/GSK-3β signaling pathway on atrial natriuretic peptide secretion in rabbits with rapid atrial pacing. Front Physiol 13:861981 (2022). PubMed: 36060704
- Dey D et al. Diffusion of small molecule drugs is affected by surface interactions and crowder proteins. iScience 25:105088 (2022). PubMed: 36157590
- Macdougall CE et al. Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell Subsets. Cell Metab 27:588-601.e4 (2018). PubMed: 29514067
- Zhang Y et al. The anti-hyperglycemic efficacy of a lipid-lowering drug Daming capsule and the underlying signaling mechanisms in a rat model of diabetes mellitus. Sci Rep 6:34284 (2016). PubMed: 27721485
- Ahmed T et al. Rescue of impaired late-phase long-term depression in a tau transgenic mouse model. Neurobiol Aging 36:730-9 (2015). PubMed: 25443285
- Foertsch F et al. S100A11 is involved in the regulation of the stability of cell cycle regulator p21(CIP1/WAF1) in human keratinocyte HaCaT cells. FEBS J 280:3840-53 (2013). PubMed: 23745637
- Collu GM et al. Dishevelled limits Notch signalling through inhibition of CSL. Development 139:4405-15 (2012). PubMed: 23132247